Pantokolcin - instructions for use, dose, side effects, contraindications

The spectrum of action is associated with the presence in the structure of gamma-aminobutyric acid. The mechanism of action is due to the direct influence of pantocalcin on GABA_B-receptor-channel complex. It has neurometabolic, neuroprotective and neurotrophic properties. Increases brain resistance to gunoxy and toxic substances, stimulates anabolic processes in neurons. Has an anticonvulsant effect, reduces motor excitability with simultaneous ordering of behavior. Increases mental and physical performance. Helps normalize the content of gamma-aminobutyric acid in chronic alcohol intoxication and subsequent abolition of ethanol. Has an analgesic effect. Is able to inhibit acetylation reactions, I participateniin the mechanisms of inactivation of novocaine and sulfanilamides, due to which the prolongation of the action of the latter is achieved. It causes inhibition of the pathologically increased vesicle reflex and detrusor tone.

Pharmacokinetics:

Quickly absorbed in the gastrointestinal tract.Time to reach the maximum concentration in the blood plasma is 1 hour. The greatest concentrations are created in the liver, kidneys, in the wall of the stomach, the skin. Penetrates through the blood-brain barrier. It is not metabolized. It is unchanged for 48 hours (67.5% of the dose taken with urine, 28.5% with feces).

Indications:

- Cognitive impairment with organic brain lesions and neurotic disorders;

- in the complex therapy of cerebrovascular insufficiency caused by atherosclerotic changes in cerebral vessels; senile dementia (initial form), residual organic brain damage in persons of mature age and elderly;

- cerebral organic insufficiency in patients with schizophrenia (in combination with neuroleptics, antidepressants);

- extrapyramidal hyperkinesis in patients with hereditary diseases of the nervous system (Huntington's chorea, hepatocerebral dystrophy, Parkinson's disease, etc.);

- consequences of the transferred neuroinfections and craniocerebral traumas (as part of complex therapy);

- for the correction of the side effect of antipsychotics and for the preventive purpose simultaneously as "cover therapy"; extrapyramidal neuroleptic syndrome (hyperkinetic and akinetic);

- ePIlepsy with a slowing of mental processes (in combination with anticonvulsants);

- psycho-emotional overload, decreased mental and physical performance; to improve concentration and memorization;

- disorders of urination: enuresis, daytime urinary incontinence, pollakiuria, imperative urges;

- children with mental retardation (delay of mental, speech, motor development or their combination); infantile cerebral palsy; stuttering (mostly clonic form); epilepsy (as part of combination therapy with anticonvulsant drugs, especially with polymorphic attacks and small epileptic seizures).

Contraindications:

- Hypersensitivity;

acute renal failure;

- Pregnancy (1 term).

Dosing and Administration:

Inside, 15-30 minutes after eating.

A single dose for adults is 0.5-1 g, for children 0.25-0.5 g, a daily dose for adults is 1.5-3 g, for children 0.75-3 g. The length of the course of treatment - from 1 to 4 months, in some cases up to 6 months. After 3-6 months, a repeat course of treatment is possible.

Children with mental insufficiency: 0.5 g 4-6 times a day, daily for 3 months, with a delay in speech development - 0.5 g 3-4 times a day for 2-3 months.

With neuroleptic syndrome (as a corrector of side effects of neuroleptic drugs): adults 0.5-1 g 3 times a day, children 0.25-0.5 g 3-4 times a day. Duration of treatment -1-3 months.

With epilepsy: children 0.25-0.5 g 3-4 times a day, adults 0.5-1 g 3-4 times a day daily for a long time (up to 6 months).

With hyperkinesis (tics): children 0.25-0.5 g 3-6 times daily for 1-4 months, adults - 1.5-3 g daily for 1-5 months.

In disorders of urination: Adults 0.5-1 g 2-3 times a day (daily dose of 2-3 g), children - 0.25-0.5 g (daily dose of 25-50 mg / kg). The duration of the course of treatment is from 2 weeks to 3 months (depends on the severity of the disorders and the therapeutic effect).

With the consequences of neuroinfections and craniocerebral injuries: on 0,25 g 3-4 times a day.

To restore working capacity under increased loads and asthenic conditions: 0.25 g three times a day.

This dosage form is not recommended for children under 3 years old.

Side effects:

Allergic reactions are possible: rhinitis, conjunctivitis, skin rashes.

Interaction:

Prolongs the action of barbiturates; enhances the effects of drugs that stimulate the central nervous system, anticonvulsant drugs, the action of local anesthetics (procaine). Prevents the side effects of phenobarbital, carbamazepine, antipsychotic drugs (neuroleptics).

The action of gopanthenic acid is enhanced in combination with glycine, xyediphon.

Form release / dosage:Tablets, 250 mg and 500 mg.

Packaging:

For 10 tablets and contour acheikova packing or in a contour acheikova packing with perforation, from a film of polyvinylchloride and a foil of aluminum printed varnished.

50 tablets are placed in cans of polymer in a set with lids.

Each jar, 5 contour packs, together with instructions for use, are placed in a pack of cardboard.

Storage conditions:

AT protected from light, at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:

4 years.

Do not use after the expiration date.

Terms of leave from pharmacies:On prescription

Registration number:P N001397 / 01

Date of registration:07.09.2007

The owner of the registration certificate:VALENTA PHARM, PAO VALENTA PHARM, PAO Russia

Manufacturer: & nbsp

VALENTA PHARMACEUTICS, JSC Russia

Representation: & nbspVALENTA PHARM, PAO VALENTA PHARM, PAO Russia

Information update date: & nbsp24.12.2015

Illustrated instructions

Instructions

Pantocalcin® (Pantocalcin®)