Pantogam - instructions for use, doses, side effects, contraindications

Pantogam (gopantenic acid) 250 mg or 500 mg, potato starch 1.86 mg or 3.72 mg, calcium stearate 4.65 mg or 9.30 mg, magnesium carbonate 53.49 mg or 106.98 mg.

Description:

Tablets of white color, flat-cylindrical, with a facet and a risk.

Pharmacotherapeutic group:nootropic remedy

ATX: & nbsp

N.06.B.X Other psychostimulants and nootropic drugs

Pharmacodynamics:

The spectrum of action of Pantogam® is related to the presence of gamma-aminobutyric acid in its structure. The mechanism of action is due to the direct influence of Pantogam® on GABA_B-receptor-channel complex. The drug has nootropic and anticonvulsant action. Pantogam ® increases the resistance of the brain to hypoxia and the effects of toxic substances, stimulates anabolic processes in neurons,combines a moderate sedative effect with a mild stimulating effect, reduces motor excitability, activates mental and physical performance. It improves the metabolism of GABA in chronic alcohol intoxication and after the abolition of ethanol. It is able to inhibit the acetylation reactions involved in the mechanisms of inactivation of novocaine and sulfonamides, thereby prolonging the action of the latter. It causes inhibition of the pathologically increased vesicle reflex and detrusor tone.

Pharmacokinetics:

Pantogam® is rapidly absorbed from the gastrointestinal tract, penetrates the blood-brain barrier, the highest concentrations are created in the liver, kidneys, in the wall of the stomach and skin. The drug is not metabolized and is excreted unchanged for 48 hours: 67.5% of the dose taken with urine, 28.5% with feces.

Indications:

- Cognitive impairment in organic brain lesions (including the consequences of neuroinfections and craniocerebral trauma) and neurotic disorders,

- schizophrenia with cerebral organic insufficiency,

- cerebrovascular insufficiency caused by atherosclerotic changes in cerebral vessels,

- extrapyramidal disorders (myoclonus epilepsy, Huntington's chorea, hepatolenticular degeneration, Parkinson's disease, etc.), as well as for the treatment and prevention of extrapyramidal syndrome (hyperkinetic and akinetic), caused by the administration of neuroleptics,

- epilepsy with a delayed mental processes, in complex therapy with anticonvulsants,

- psycho-emotional overload, a decrease in mental and physical performance, to improve concentration and memorization,

- neurogenic disorders of urination (pollakiuria, imperative urges, mandatory urinary incontinence, enuresis),

- children with perinatal encephalopathy, mental retardation of varying severity, with developmental delay (mental, speech, motor or combination), with various forms of infantile cerebral palsy, hyperkinetic disorders (attention deficit hyperactivity disorder), neurosis-like conditions (stuttering, mainly clonic form, tics). The drug is used in children older than 3 years. At an earlier age, it is recommended that the drug be administered as a syrup.

Contraindications:

- Hypersensitivity;

- Acute severe kidney disease;

- Pregnancy, lactation.

Dosing and Administration:

Inside 15-30 minutes after eating.

Single dose for adults is usually 0.25-1 g, for children - 0.25-0.5 g; daily intake for adults - 1,5-3 g, for children - 0,75-3 g. The course of treatment - from 1 to 4 months, in some cases - up to 6 months. After 3-6 months, a repeat course of treatment is possible.

With epilepsy in combination with anticonvulsants in a dose of 0.75 to 1 g per day. The course of treatment is up to 1 year and more.

With extrapyramidal neuroleptic syndrome in combination with ongoing therapy, daily dose to 3 g, treatment for several months.

When extrapyramidal hyperkinesis in patients with hereditary diseases of the nervous system in combination with the current therapy from 0.5 to 3 grams per day. The course of treatment up to 4 months or more.

At the consequences of neuroinfections and craniocerebral injuries 0.25 g 3-4 times a day.

To restore working capacity under increased loads and asthenic conditions Pantogam® appoint 0.25 g 3 times a day.

For the treatment of extrapyramidal syndrome caused by the administration of neuroleptics: adults 0.5 - 1 g 3 times a day, children - 0.25-0.5 g 3-4 times a day. The course of treatment is 1-3 months.

With ticks: children 0.25-0.5 g 3-6 times a day for 1-4 months, adults 1.5-3 g per day, for 1-5 months.

In cases of urination disorders: adults 0.5-1 g 2-3 times a day, children 0.25-0.5 grams (daily dose is 25-50 mg / kg). The course of treatment is from 1 to 3 months.

Children with various pathologies of the nervous system depending on the age of the drug is recommended in a dose of 1-3 g. Tactics of the drug: a dose increase for 7-12 days, taking in the maximum dose for 15-40 days and gradually reducing the dose until the removal of Pantogam® within 7-8 days . The break between the exchange rate of Pantogam®, as well as for any other nootropic remedy, is from 1 to 3 months.

In the conditions of long-term treatment, simultaneous administration of the drug with other nootropic and stimulating agents is not recommended.

Taking into account the nootropic effect of the drug, it is preferably administered in the morning and afternoon.

Side effects:

Allergic reactions (rhinitis, conjunctivitis, skin rashes) are possible. In this case, reduce the dose or cancel the drug.

Sleep disturbances or drowsiness, noise in the head - these symptoms are usually short-lived and do not require withdrawal of the drug.

Overdose:

Increased symptoms of side effects.

Treatment: Activated carbon, gastric lavage, symptomatic therapy.

Interaction:

Prolongs the effect of barbiturates, enhances the action of anticonvulsants, prevents side effects of phenobarbital, carbamazepine, neuroleptics.

The effect of Pantogam® is enhanced in combination with glycine, xydiphon.

Potentiates the action of local anesthetics (novocain).

Form release / dosage:

Tablets, 250 mg and 500 mg.

Packaging:

For 50 tablets in cans of glass-colored orange with a screw neck, sealed with screwed plastic caps and gaskets with cardboard sealing with double-sided polyethylene coating.

Each bank with instructions for use is placed in a pack of cardboard box.

For 10 tablets in a contour mesh box made of polyvinylchloride film and aluminum foil printed and lacquered.

For 5 contour mesh packages together with the instruction for use are placed in a pack of cardboard.

Storage conditions:

In a dry, the dark place at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:

3 years.

Do not use after expiry date.

Terms of leave from pharmacies:On prescription

Registration number:P N003489 / 01

Date of registration:16.07.2009

The owner of the registration certificate:PIK-PHARMA, LLC PIK-PHARMA, LLC Russia

Manufacturer: & nbsp

TsNKB FSUE Russia

Representation: & nbspPIK-PHARMA LLC PIK-PHARMA LLC Russia

Information update date: & nbsp23.12.2015

Illustrated instructions

Instructions

Pantogam® (Pantogam®)