Immunoglobulin is injected intramuscularly into the upper outer quadrant of the gluteus muscle or the external surface of the thigh. Do not administer the drug intravenously.
Before the injection, the ampoule with the drug is kept for 2 hours at room temperature 20 ± 2 ° C. To prevent the formation of foam, the drug is drawn into the syringe with a needle with a wide lumen. The drug in the opened ampoule is not subject to storage.The preparations in ampoules with broken integrity or marking are not suitable for use in changing physical properties (color change, cloudiness of solution, presence of non-breaking flakes), expired shelf life, and improper storage.
The dosage of the drug and the frequency of its administration depend on the indications for use.
Prevention of hepatitis A
The drug is administered once in the following amounts: children from 1 to 6 years - 0.75 ml (1/2 dose); from 7 to 10 years - 1.5 ml (1 dose); older than 10 years and adults - 3 ml (2 doses). Repeated administration of immunoglobulin according to indications - not earlier than in 2 months.
Prevention of measles
The drug is administered once, from 3 months of age, not measles and unvaccinated, no later than 4 days after contact with the patient. Dosage of the drug to children (1.5 or 3.0 ml) is determined depending on the state of health and the time elapsed from the time of contact with the patient. Adults, as well as children in contact with mixed infections, the drug is administered in a volume of 3.0 ml (2 doses).
Prevention and treatment of influenza
The drug is administered once in amounts: to children under 2 years - 1.5 ml (1 dose); from 2 to 7 years - 3.0 ml (2 doses); older than 7 years and adults - 4.5-6.0 ml (3-4 doses).In the treatment of severe forms of influenza, repeated (24-48 hours) administration of immunoglobulin at the same dosage is indicated.
Prophylaxis of pertussis
The drug is injected twice with an interval of 24 hours in a single dose of 3.0 ml (2 doses) to children who have not had pertussis, at the earliest possible time after contact with the patient.
Prevention of meningococcal infection
The drug is administered once to children aged 6 months to 7 years, not later than 7 days after contact with the patient, the generalized form of meningococcal infection at a dosage of 1.5 ml (1 dose) to children under 3 years and 3.0 ml (2 doses) - Children over 3 years.
Prevention of poliomyelitis
The drug is administered once in an amount of 3.0-6.0 ml (2-4 doses) of an unvaccinated or inferiorly vaccinated poliomyelitis vaccine to children at the earliest possible time after contact with the patient with a paralytic form of poliomyelitis.
Treatment of hypo - and agammaglobulinemia
The drug is administered in an amount of 1.0 ml per kg of body weight; The calculated dose can be administered in 2-3 doses at intervals of 24 hours. The subsequent administration of immunoglobulin is carried out according to the indications no earlier than one month later.
Increase of resistance of the organism during the reconvalescence of acute infectious diseases with prolonged course and with chronic and protracted pneumonia
The drug is administered in a dosage of 0.15-0.2 ml per 1 kg of body weight. Multiplicity of administration (up to 4 injections) is determined by the doctor; the interval between / injections is 2-3 days.