The drug is administered intramuscularly, in the upper outer quadrant of the gluteus muscle or in the external surface of the thigh. Do not administer the drug intravenously!
Before the injection, the ampoule with the drug is kept for 2 hours at room temperature. Opening of ampoules and the procedure of administration are carried out with strict adherence to aseptic and antiseptic rules. To prevent the formation of foam, the drug is drawn into the syringe with a needle with a wide lumen. The drug in the opened ampoule is not subject to storage.
The preparation is not suitable for use in ampoules with broken integrity, marking, and also when physical properties change (color change, cloudiness of solution, presence of unbreakable flakes), expired shelf life and non-observance of storage conditions.
The dose of immunoglobulin and the frequency of its administration depend on the indications for use.
Prevention of hepatitis A. The drug is administered once in doses: children from 1 to 6 years - 0.75 ml; 7-10 years - 1.5 ml; older than 10 years and adults - 3.0 ml. Repeated administration of immunoglobulin in case of need of prophylaxis of hepatitis A is shown not earlier than in 2 months.
Prevention of measles. The drug is administered only once from 3 months of age to persons who are not infected with measles and not vaccinated against this infection, no later than 6 days after contact with the patient. The dose of the drug to children (1.5 or 3.0 ml) is determined depending on the health status and the time elapsed since the contact. Adults, as well as children in contact with mixed infections, the drug is administered in a dose of 3.0 ml.
Prophylaxis of pertussis. The drug is injected twice with an interval of 24 hours in a single dose of 3.0 ml to children who have not had pertussis and who are not vaccinated (not fully vaccinated) against pertussis at the earliest possible time after contact with the patient, but not later than 3 days.
Prevention of meningococcal infection. The drug is administered once to children aged 6 months to 7 years, not later than 7 days after contact with the patient with a generalized form of meningococcal infection at doses of 1.5 ml (children up to 3 years) and 3.0 ml (children over 3 years old).
Prevention of poliomyelitis. The drug is administered once in a dose of 3.0-6.0 ml of non-grafted or inferiorly grafted poliomyelitis vaccine to children at the earliest possible time after contact with a patient with poliomyelitis.
Prevention and treatment of influenza. The drug is administered once at doses: children up to 2 years - 1.5 ml; from 2 up to 7 years - 3.0 ml; older than 7 years and adults - 4,5-6.0 ml. In the treatment of severe forms of influenza, a second 24-48 h) administration of immunoglobulin in the same dose.
Treatment of hypo-and agammaglobulinemia. The drug is administered in a dose of 1.0 ml / kg of body weight; the calculated dose can be administered in 2-3 doses at an interval of 24 h. Subsequent immunoglobulin administration is carried out according to the indications no earlier than 1 month later.
Increase of resistance of the organism in the period of reconvalescence of acute infectious diseases with prolonged course and with chronic pneumonia. The drug is administered in a single dose of 0.15-0.2 ml / kg body weight. Multiplicity of administration (up to 4 injections) is determined by the attending physician, the intervals between injections are 2-3 days.