The dose of the drug and the frequency of its administration depend on the indications for use.
Prevention of hepatitis A
The drug is administered once in doses: children from 1 to 6 years - 0.75 ml, up to 10 years - 1.5 ml, over 10 years and adults - 3 ml. Repeated administration of immunoglobulin in case of need of prophylaxis of hepatitis A is shown not earlier than in 2 months.
Prevention of measles
The drug is administered once from 3 months of age to persons who are not infected with measles and not vaccinated against the infection, no later than 6 days after contact with the patient.The dose of the drug to children (1.5 or 3 ml) is determined depending on the health status and the time elapsed from the moment of contact. Adults, and also children, in contact with mixed infections, the drug is administered in a dose of 3 ml.
Prevention and treatment of influenza
The drug is administered once in doses: children under 2 years - 1.5 ml, from 2 to 7 years - 3 ml, over 7 years and adults - 4.5-6 ml. In the treatment of severe forms of influenza, repeated (24-48 h) administration of immunoglobulin at the same dose is indicated.
Prophylaxis of pertussis
The drug is administered twice with an interval of 24 hours in a single dose of 3 ml to children who have not had pertussis, at the earliest possible time of contact with the patient.
Prevention of meningococcal infection
The drug is administered once in doses to children aged 6 months to 7 years, not later than 7 days after contact with the patient with a generalized form of meningococcal infection in doses of 1.5 ml for children under 3 years and 3 ml for children over 3 years old.
Prevention of poliomyelitis
The drug is administered once in doses of 3-6 ml of an unvaccinated or inferiorly vaccinated poliomyelitis vaccine to children at the earliest possible time after contact with the patient with a paralytic form of poliomyelitis.
Treatment of hypo- and agammaglobulinemia
The drug is administered in a dose of 1 ml per 1 kg of body weight, the calculated dose can be administered in 2-3 doses at an interval of 24 h. Subsequent immunoglobulin administration is carried out according to indications no earlier than one month.
Increase of resistance of the organism during the reconvalescence of acute infectious diseases with prolonged course and with chronic and protracted pneumonia
The drug is administered in a single dose of 0.15-0.2 ml per 1 kg of body weight. Multiplicity of administration (up to 4 injections) is determined by the doctor; intervals between injections are 2-3 days.
Immunoglobulin is injected intramuscularly into the upper outer quadrant of the gluteus muscle or the external surface of the thigh. Do not administer the drug intravenously.
Prior to the beginning of the administration, the ampoule with the preparation is kept for 2 hours at room temperature (18-22) ° C.
To prevent the formation of foam, the drug is drawn into the syringe with a needle with a wide lumen.
The drug in the opened ampoule is not subject to storage.
Persons receiving the drug should be monitored for 30 minutes; In the room where the drug is injected, anti-shock therapy should be available. With the development of anaphylactic reactions, antihistamines are used,glucocorticosteroids and adrenomimetics.
Indication of the features of the drug during the first admission or when it is withdrawn
The maximum concentration of antibodies in the blood is reached after - 24 hours, the half-life of antibodies from the body is 4-5 weeks. Temporary increase of the content of introduced antibodies in the blood of the patient after the administration of immunoglobulin can cause false positive results of serological tests.