Contratex (Kontratex)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceBenzalkonium chlorideBenzalkonium chloride
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    • Dosage form: & nbspVaginal suppositories
    Composition:

    For one suppository:

    Active substance:

    Benzalkonium chloride (Benzalkonium chloride C14) (in terms of 100% substance) -18.9 mg.

    Excipients:

    Benzoic acid - 1,125 mg.

    Solid fat is a sufficient amount to produce a suppository weighing 1.5 g.

    Description:Suppositories white or white with a yellowish tint of color, torpedo-shaped, with a weak specific odor.
    Pharmacotherapeutic group:Contraceptive for topical use
    ATX: & nbsp

    D.08.A.J.01   Benzalkonium chloride

    G.02.B.B   Intravaginal contraceptives

    Pharmacodynamics:

    Benzalkonium chloride antiseptic, also antifungal, antiprotozoal, contraceptive local (spermatocidal) effect; Inactivates the Herpes simplex virus.

    It shows bactericidal activity against staphylococci, streptococci, gram-negative bacteria (intestinal and pseudomonas aeruginosa, proteus, klebsiella, etc.), anaerobic bacteria, fungi and molds. It acts on strains of bacteria resistant to antibiotics and other chemotherapeutic drugs; suppresses plasmacoagulase and hyaluronidase of staphylococci. Prevents secondary infection of wounds by hospital strains of microorganisms.

    Spermatocidal effect is due to the ability to damage the membranes of spermatozoa (at the beginning of the flagella, then the head),which makes it impossible to fertilize a damaged sperm cell. The effect develops after 5 minutes (vaginal suppositories).

    In vjtro is active against Neisseria gonorrhoeae, Chlamydia spp., Trichomonas vaginalis, Herpes simplex type 2, Staphylococcus aureus. It does not affect Mycoplasma spp. and weakly affects Gardnerella vaginalis, Candida albicans, Haemophilus ducreyi and Treponema pallidum.

    In vivo shows some activity in the prevention of some sexually transmitted diseases. Does not affect the normal microflora of the vagina (including the Doderylein wand) and the hormonal cycle.

    Pharmacokinetics:Virtually not absorbed with intravaginal injection, removed by simple water washing and with normal physiological secretions.
    Indications:Local contraception for women of reproductive age (contraindications to the use of oral contraceptives or IUDs, postpartum period, lactation period, post-abortion period, pre-menopause, need for occasional protection from pregnancy, missed or late receipt of ever-used oral contraceptives).
    Contraindications:Hypersensitivity, colpitis, ulceration and irritation of the mucous membrane of the vagina and uterus.
    Pregnancy and lactation:Harmful effect on the course of pregnancy does not have. It is not excreted in breast milk, it can be used during lactation.
    Dosing and Administration:

    Intravaginal (for the purpose of contraception).

    Lying on the back, the candle is injected deep into the vagina for 5 minutes before sexual intercourse; the duration of the action is 4 hours. It is obligatory to introduce a new candle in case of repeated sexual acts.

    Side effects:Allergic reactions, contact dermatitis, candidiasis, vulvovaginitis.
    Interaction:Any drug administered intravaginally can reduce the local spermicidal effect (including soap and solutions containing it).
    Special instructions:To increase the efficiency, careful compliance with the method of application of the preparation is necessary. It is possible to use together with the vaginal diaphragm or IUD. Do not wash or water the vagina with soapy water. soap destroys the active substance of the drug (outdoor toilet is possible only with clean water).
    Form release / dosage:Suppositories are vaginal.
    Packaging:5 pieces in a planar cell package. 2 contour packs with instructions for use are placed in a pack of cardboard.
    Storage conditions:List B.In a dry place, protected from light, out of reach of children, at a temperature not exceeding 25 ° C.
    Shelf life:2 years. Do not use the drug after the expiration date.
    Terms of leave from pharmacies:Without recipe
    Registration number:LSR-006072/08
    Date of registration:31.07.2008
    Expiration Date:Unlimited
    The owner of the registration certificate:MOSCOW PHARMACEUTICAL FACTORY, CJSC MOSCOW PHARMACEUTICAL FACTORY, CJSC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp03.02.2018
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