Nystatin (Nystatin)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceNystatinNystatin
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    • Dosage form: & nbspfilm coated tablets
    Composition:

    One tablet contains:

    Active substance:

    Nystatin

    - 55.5 mg (250000ED)

    111 mg (500,000 ED)

    Auxiliary substances of the core:

    lactose monohydrate (milk sugar)

    - 28.8 mg

    - 57.60 mg

    magnesium hydroxycarbonate (magnesium carbonate basic)

    - 12 mg

    - 24 mg

    hypromellose (hydroxypropylmethylcellulose)

    -1.2 mg

    -2.4 mg

    calcium stearate

    - 1.2 mg

    - 2.4 mg

    potato starch

    - 21.3 mg

    - 42.6 mg

    Shell accessories:

    lactose monohydrate (milk sugar)

    - 0.885 mg

    - 1.77 mg

    hypromellose (hydroxypropylmethylcellulose)

    - 3.143 mg

    - 6.286 mg

    titanium dioxide

    - 0.265 mg

    - 0.53 mg

    polysorbate 80 (Tween 80)

    - 0.315 mg

    - 0.63 mg

    magnesium hydrosilicate (talc)

    - 0.265 mg

    - 0.53 mg

    vanillin

    - 0.12 mg

    - 0.24 mg

    dye quinoline yellow, E 104

    0.0035 mg

    0.007 mg

    dye tropeolin O

    0.0035 mg

    0.007 mg
    Description:

    The tablets covered with a film cover, light yellow color with a greenish shade, with a slight smell of vanillin.

    Pharmacotherapeutic group:Antifungal antibiotic
    ATX: & nbsp

    G.01.A.A   Antibiotics

    G.01.A.A.01   Nystatin

    Pharmacokinetics:

    Nystatin - 19-mycosaminilistinatanolide refers to the antibiotic polyene group produced by actinomycete Streptomyces noursei.

    Nystatin has a fungistatic effect on yeast-like fungi Candida. The drug is poorly absorbed from the gastrointestinal tract. The bulk of the drug taken orally, excreted with feces. Nystatin does not possess cumulative properties.

    Indications:

    - Candidiasis of the mucous membranes of the skin and internal organs.

    - Prevention of the development of candidiasis with prolonged treatment with antibacterial agents especially in exhausted and weakened patients (with a preventive goal).

    Contraindications:- Hypersensitivity.

    - Impaired liver function, pancreatitis.

    - Stomach ulcer and duodenal ulcer.

    - Children under 3 years.

    - Pregnancy.

    - Lactose intolerance, lactase deficiency, glucose-galactose malabsorption.
    Carefully:With caution should be used in cases of kidney disease, with leukopenia (a decrease in the level of leukocytes in the blood).
    Pregnancy and lactation:

    Nystatin is contraindicated in pregnancy.

    There is no data on the isolation of Nystatin with breast milk, therefore, if Nystatin is needed during lactation, the question of stopping breastfeeding should be addressed.
    Dosing and Administration:

    For the treatment of candidiasis of internal organs nystatin used inside regardless of food intake.

    Adults are prescribed 111 mg (500,000 units) 3-4 times or 55.5 mg (250,000 units) 6-8 times a day. With generalized candidiasis, the daily dose can be increased to 6,000,000 units.

    Children aged 3 to 13 years at 55.5 mg (250 000 units) 3-4 times a day, from 13 years and older - 55.5 mg - 111 mg (250 000 units - 500 000 units) 3-4 times a day. The duration of the course of treatment is 10-14 days. If necessary, the course can be repeated in a week.

    Side effects:With the intake of nystatin, nausea, vomiting, chills, diarrhea, skin itching are possible. In these cases, reduce the dose or cancel the drug.
    Overdose:Currently, cases of drug overdose Nystatin not reported.
    Interaction:

    There is cross-resistance with amphotericin B.

    With simultaneous application of Nystatin with clotrimazole, the activity of the latter decreases.

    Effect on the ability to drive transp. cf. and fur:There is no evidence that the drug can adversely affect drivers and people working with machinery.
    Form release / dosage:

    Film coated tablets, 250,000 units and 500,000 units.

    Packaging:

    For 10, 20, 30, 50 or 100 tablets in a jar of dark glass or in a polymer can of polyethylene or polypropylene.

    For 10 tablets in a contoured cell packaging made of polyvinylchloride film and aluminum foil printed lacquered or paper with polyethylene coating.

    1 bank or 1, 2, 3, 5, 10 contour mesh packages together with instructions for use are placed in a pack of cardboard.

    Storage conditions:In a dry, protected from light place at a temperature of no higher than 25 ° C. Keep out of the reach of children.
    Shelf life:2 years. Do not use after the expiry date printed on the package.
    Terms of leave from pharmacies:On prescription
    Registration number:P N000840 / 03
    Date of registration:07.08.2008 / 28.02.2018
    Expiration Date:Unlimited
    The owner of the registration certificate:BIOSINTEZ, PAO BIOSINTEZ, PAO Russia
    Manufacturer: & nbsp
    Information update date: & nbsp21.06.2018
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