Active substanceNystatinNystatin Similar drugsTo uncover Macmirror Complex capsules the vagina. Polikem Sr.L. Italy Nystatin pills inwards BIOCHEMIST, OJSC Russia Nystatin pills inwards BORISOVSKIY FACTORY OF MEDPREPARATES, OJSC Republic of Belarus Nystatin pills inwards BELMEDPREPARATY, RUP Republic of Belarus Nystatin ointment externally BIOCHEMIST, OJSC Russia Nystatin ointment externally BIOSINTEZ, PAO Russia Nystatin pills inwards BIOSINTEZ, PAO Russia Nystatin suppositories the vagina. BIOSINTEZ, PAO Russia Nystatin suppositories rect. BIOSINTEZ, PAO Russia Nystatin pills inwards AVEKSIMA, JSC Russia Dosage form: & nbspVaginal suppositories Composition:For one suppository. Active substance: Nystatin - 55.5 mg (250,000 IU) - 111.0 mg (500,000 IU) Excipients: propyl parahydroxybenzoate (nipazole) 2.0 mg 2.0 mg citric acid monohydrate - 0.075 mg - 0.075 mg The basis for suppositories: hard fat - a sufficient amount until a suppository with a mass of 2.4 g Note. The amount of nystatin is indicated for a drug with an activity of 4500 U / mg in terms of dry matter. In the case of the use of higher activity nystatin, the amount thereof is correspondingly reduced, increasing the amount of the base. Description:Suppositories yellow, torpedo-shaped, with a maximum diameter of 1.5 cm. Pharmacotherapeutic group:Antifungal agent ATX: & nbspG.01.A.A AntibioticsG.01.A.A.01 Nystatin Pharmacodynamics:Polyene antifungal antibiotic, highly active against yeast-like fungi of the genus Candida. In the structure of the antibiotic are double bonds having a high affinity for cell membrane sterol of fungi structures, which contributes to the incorporation of the drug molecule in the cell membrane and the formation of a large number of channels through which the uncontrolled transport of electrolytes; an increase in osmolarity within the cell leads to its death. Resistance develops very slowly. Pharmacokinetics:When topical application is practically not absorbed through the mucous membranes. Indications:Treatment and prevention (with prolonged local antimicrobial therapy) candidiasis of the vaginal mucosa. Contraindications:Hypersensitivity to the drug, pregnancy, children under 18 years (no data on the efficacy and safety of Nystatin in the formulation for intravaginal use in children). Carefully: Pregnancy and lactation:The drug is contraindicated in pregnancy.Application in the period of breastfeeding is possible, since the drug is almost not absorbed through the mucous membranes, so it does not penetrate breast milk. Dosing and Administration:Vaginally. A suppository that has been previously released from the contour cell package with scissors (cutting the package along the contour of the suppository) is introduced into the vagina (after hygienic procedures) 1 suppository 2 times a day (morning and evening). The course of treatment is 10-14 days. Side effects:Local reactions of hypersensitivity are possible. The risk of spreading resistant forms of fungi is possible, which requires the discontinuation of the drug. Interaction:With the simultaneous use of nystatin with clotrimazole, the activity of the latter decreases. Special instructions:During menstruation, treatment should not be interrupted. In fungal diseases of the vagina, simultaneous treatment of the sexual partner is recommended. During the period of treatment it is recommended to avoid sexual contact. Effect on the ability to drive transp. cf. and fur:During the treatment with the drug, it is possible to manage motor vehicles and engage in other potentially hazardous activities,requiring increased concentration of attention and speed of psychomotor reactions. Form release / dosage:Vaginal suppositories 250 000 units and 500 000 units. Packaging:There are 5 suppositories in a contiguous cell package.2 contour squares, together with instructions for use, are placed in a cardboard box. Storage conditions:In a dry, dark place at a temperature of no higher than 20 ° C. Keep out of the reach of children. Shelf life:2 years. Do not use after the expiry date printed on the package. Terms of leave from pharmacies:On prescription Registration number:P N000840 / 02 Date of registration:28.04.2008 / 05.02.2018 Expiration Date:Unlimited The owner of the registration certificate:BIOSINTEZ, PAO BIOSINTEZ, PAO Russia Manufacturer: & nbspBIOSINTEZ, PAO Russia Information update date: & nbsp21.06.2018 Illustrated instructions × Illustrated instructions Instructions