Oftan® Katachrom (Oftan® Catachrom)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceAdenosine + Nicotinamide + Cytochrome CAdenosine + Nicotinamide + Cytochrome C
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  • Oftan® Katachrom
    drops d / eye 
    Santen, AO     Finland
    • Dosage form: & nbsp

    eye drops

    Composition:

    1 ml of the preparation contains:

    Active substances:

    Adenosine 2.0 mg, nicotinamide 20.0 mg, cytochrome C 0.675 mg.

    Excipients:

    Benzalkonium chloride 0.04 mg, sodium succinate hexahydrate 1.0 mg, sorbitol 10.0 mg, sodium dihydrogen phosphate dihydrate 4,415 mg, sodium hydrogen phosphate dihydrate 2,847 mg, water for injection up to 1 ml.

    Description:Transparent solution of red color.
    Pharmacotherapeutic group:Reparation of tissue stimulant
    ATX: & nbsp

    S.01.X   Other drugs for the treatment of eye diseases

    Pharmacodynamics:

    Combined drug that improves the energy metabolism of the lens. Cytochrome C plays an important role in biochemical oxidation-reduction processes in the tissues of the eyeball and is an antioxidant. Adenosine - the precursor of adenosine triphosphate (ATP), takes part in the metabolic processes of the lens. Nicotinamide stimulates the synthesis of nicotinamide-dinucleotide (NAD), cofactor dehydrogenases.

    Pharmacokinetics:

    When topical application of cytochrome C is not absorbed into the systemic circulation, the body is metabolized completely. The disintegration of cytochrome C proceeds along the same metabolic pathways as the cleavage of amino acids, and the heme, digested to bilirubin, is excreted with bile.

    Adenosine freely passes through the cornea. The half-life of adenosine from the plasma is less than one minute, it is metabolized in virtually all tissues with the formation of inosine, xanthine and urate freely released in the urine. Ribose, which is a constituent element of adenosine, is metabolized to glyceraldehyde-3-phosphate, then to pyruvate and burned in the Krebs cycle.

    Nicotinamide is partially metabolized to nicotinic acid. Both these compounds are methylated in N-methyl nicotinamide, which subsequently decomposes in the liver. Metabolites and unchanged nicotinamide excreted by urine.

    Indications:

    Cataract of various genesis.

    Contraindications:

    Individual hypersensitivity to the components of the drug; Children under 18 years of age (due to the lack of data on the efficacy and safety of the drug in children and adolescents under 18 years).

    Pregnancy and lactation:

    Sufficient experience in the use of the drug during pregnancy and lactation is not present. It is possible to use Oftan® Catachrome for the treatment of pregnant and lactating mothers as prescribed by the attending physician,if only the expected curative effect for the mother justifies the potential risk to the fetus and the baby.

    Dosing and Administration:

    Locally, 1-2 drops in the conjunctival sac 3 times a day.

    When using the vial for the first time, turn the lid of the vial at the same time pressing down and then open the vial.

    Side effects:

    From the eyes: short-term burning and tingling of the eyes, allergic conjunctivitis, contact dermatitis.

    Systemic side effects are extremely rare. There may be short-term nausea, arterial hypotension, dizziness and shortness of breath. A nicotinic acid has a vasodilator effect and can cause a feeling of heat, fainting and a sensation of pulsation in the temples.

    Overdose:There is no evidence of an overdose of the drug.
    Interaction:

    There were no clinically significant interactions with other drugs.

    Special instructions:

    If the patient wears soft contact lenses, he should not use eye drops Ophthan ® Catachrome, since the preservative can be deposited in soft contact lenses and adversely affect the eye tissue.

    It is necessary to remove contact lenses before instilling the drug and to dress them again only 15 minutes after the instillation of the drug.

    Patients who, after instillation of the drug, have a short-term eye irritation, should not drive the car, work with machinery, machines or any other equipment that requires good visual acuity immediately after the application of eye drops.

    Effect on the ability to drive transp. cf. and fur:

    Patients who, after instillation of the drug, have a short-term eye irritation, should not drive the car, work with machinery, machines or any other equipment that requires good visual acuity immediately after the application of eye drops.

    Form release / dosage:

    Eye drops.

    Packaging:

    For 10 ml in a polyethylene bottle, with a built-in dropper with a screw cap. The bottle with instructions for use is placed in a cardboard box.

    When using the vial for the first time, turn the lid of the vial at the same time pressing down and then open the vial.
    Storage conditions:

    Store at a temperature of 8 to 15 ° C, out of the reach of children.

    Shelf life:

    3 years. After opening the bottle - 1 month.

    Do not use after the expiry date printed on the package.

    Terms of leave from pharmacies:Without recipe
    Registration number:P N 015553/01
    Date of registration:28.05.2009 / 17.02.2015
    Expiration Date:Unlimited
    The owner of the registration certificate: Santen, AO Santen, AO Finland
    Manufacturer: & nbsp
    Representation: & nbspSANTEN AS SANTEN AS Finland
    Information update date: & nbsp20.06.2017
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