Included in the formulation
Included in the list (Order of the Government of the Russian Federation No. 2782-r of 30.12.2014):VED
АТХ:D.08.A.X Other antiseptics and disinfectants
D.08.A.X.06 Potassium permanganate
Pharmacodynamics:In contact with organic substances, the release of atomic oxygen, the oxidation of organic substrates.
Pharmacokinetics:If ingested, absorbed, leads to the development of methemoglobinemia.
Indications:Washing of wounds, ulcers, burns; douching and washing in gynecological and urological practice; gastric lavage for poisoning caused by ingestion of morphine, aconitine and other alkaloids, as well as phosphorus.
X.J00-J06.J03 Acute tonsillitis
X.J00-J06.J06.8 Other acute upper respiratory tract infections of multiple localization
XII.L80-L99.L98.4 Chronic skin ulcer, not elsewhere classified
XIV.N30-N39.N34 Urethritis and urethral syndrome
XIV.N70-N77.N76 Other inflammatory diseases of the vagina and vulva
XIX.T20-T32 Thermal and chemical burns
XIX.T51-T65.T57.1 The toxic effect of phosphorus and its compounds
XIX.T51-T65.T65.0 Toxic effect of cyanides
XIX.T51-T65.T65.2 Toxic effect of tobacco and nicotine
XIX.T79.T79.3 Post-traumatic wound infection, not elsewhere classified
Contraindications:Hypersensitivity to potassium permanganate.
Pregnancy and lactation:Adequate and well-controlled studies in humans and animals have not been conducted. There is no information on the penetration into breast milk.
Action category for the fetus by FDA - AT.
Dosing and Administration:Outwardly (in aqueous solutions): 0.1-0.5% for washing the wounds, 0.01-0.1% for rinsing the mouth and throat, 2-5% for lubricating the ulcer and burn surfaces, for douching and washing - 0,02-0,1%.
Side effects:Allergic reactions, when using concentrated solutions - burn and irritation.
Overdose:If ingested, there is a sharp pain in the oral cavity, along the esophagus, in the abdomen, vomiting, diarrhea; the mucous membrane of the mouth and throat - edematic, dark brown, violet, it is possible to swell the larynx and the development of mechanical asphyxia, burn shock, motor excitement, seizures.Often there is severe pneumonia, hemorrhagic colitis, nephropathy, hepatopathy, the phenomenon of parkinsonism. With reduced acidity of gastric juice, the development of methemoglobinemia with pronounced cyanosis and dyspnea is possible. The lethal dose for children is about 3 g, for adults - 0.3-0.5 g / kg.
As an antidote used methylene blue (50 ml of 1% solution), ascorbic acid (intravenously - 30 ml of a 5% solution), vitamin B12 - up to 1000 mcg, B6 (3 ml of a 5% solution intramuscularly).
Interaction:It is necessary to exclude the contact of sodium thiosulfate in the form of a solution for intravenous administration with potassium permanganate.
Special instructions:Even with high dilution, potassium permanganate solution, when applied externally, stains the skin brown. Symptoms of intoxication, which can develop with the intake of potassium permanganate solution in excessively high concentrations: nausea, vomiting with a brownish admixture; erosion, edema, brown coloration of the oral mucosa, gastrointestinal bleeding, damage to the liver and kidneys, inhibition of the heart.
Potassium permanganate solution can not be used as a means for abortion,because the introduction of the drug in high concentrations in the vagina causes a deep burn, heavy bleeding and perforation of the vaginal wall, which can lead to peritonitis; a vascular collapse is also possible.