Cocarboxylase - instructions for use, dose, side effects, contraindications

Coenzyme formed in the body from thiamine. Has a metabolic action, activates tissue metabolism. In the body it is phosphorylated to form mono-, di- and triphosphoric esters; cocarboxylase is part of the enzymes that catalyze the carboxylation and decarboxylation of keto acids, pyruvic acid, promotes the formation of acetyl-coenzyme A, which determines its participation in carbohydrate metabolism. Participation in the pentose cycle indirectly promotes the synthesis of nucleic acids, proteins and lipids.

Improves the absorption of glucose, trophic nervous tissue, contributes to the normalization of the functions of the cardiovascular system.

Cocarboxylase deficiency causes an increase in the level of pyruvic acid and lactic acid in the blood, which leads to metabolic acidosis.

Pharmacokinetics:

Not studied.

Indications:

In the combination therapy: metabolic acidosis, acidosis in hyperglycemic coma, acidosis with respiratory and pulmonary heart failure; Chronic heart failure, ischemic heart disease, unstable angina, myocardial infarction, postinfarction cardiosclerosis, hepatic and / or renal failure, acute and chronic alcoholism, poisoning, cardiac glycosides and barbiturate intoxication, infectious diseases (diphtheria, scarlet fever, typhoid fever, paratyphoid), neuralgia, multiple sclerosis, peripheral neuritis.

In newborns: perinatal hypoxic encephalopathy, respiratory failure, pneumonia, sepsis, hypoxia, acidosis.

ICD-10

I.A00-A09.A01 Typhus and paratyphoid

I.A30-A49.A36 Diphtheria

I.A30-A49.A38 Scarlet fever

IV.E70-E90.E87.2 Acidosis

XXI.Z70-Z76.Z71.4 Counseling and monitoring about alcoholism

XXI.Z40-Z54.Z50.2 Rehabilitation of people with alcoholism

VI.G35-G37.G35 Multiple sclerosis

XVI.P20-P29.P22 Breathing disorder in a newborn [distress]

Contraindications:

Hypersensitivity.

Carefully:

No data.

Pregnancy and lactation:

The FDA recommendation category is C.

The use of the drug is acceptable in pregnancy and during breastfeeding, if necessary.

Dosing and Administration:

Adults are given intramuscularly or intravenously. The dose is 50-200 mg per day. In diabetes (acidosis, coma), the daily dose can be 0.1-1 g. The frequency and duration of use depends on the indications.

Children - intramuscularly, intravenously (drip or jet), newborns - sublingually. Children up to 3 months - 25 mg per day, from 4 months to 7 years - 25-50 mg per day, from 8 to 18 years - 50-100 mg per day. Duration of treatment - from 3-7 to 15 days.

Side effects:

Possible: allergic reactions (hives, itching).

With intramuscular injection: possible hyperemia, itching, swelling at the injection site.

Overdose:

Not described.

Interaction:

Strengthens cardiotonic action of cardiac glycosides and improves their tolerability.

Special instructions:

It is used mainly as part of complex therapy.

Instructions

Cocarboxylase (Cocarboxylasum)