Kokarboksilaza - coenzyme thiamine (vitamin B1), has a metabolic effect, activates tissue metabolism. In the body it is phosphorylated to form mono-, di- and triphosphoric esters; cocarboxylase is part of the enzymes that catalyze the carboxylation and decarboxylation of keto acids, pyruvic acid, promotes the formation of acetyl-coenzyme A, which determines its participation in carbohydrate metabolism. Participation in the Krebs cycle indirectly promotes the synthesis of nucleic acids, proteins and lipids. Exogenous vitamin B1 (thiamine) to participate in these processes should phosphorylation of the metabolite in the cocarboxylase is a ready-made form of coenzyme. It should be noted that the properties of cocarboxylase are only partially adequate to those of thiamine; cocarboxylase is not used for the prevention and treatment of hypo- and avitaminosis B1.
Kokarboksilaza improves the absorption of glucose, trophic nervous tissue, contributes to the normalization of the functions of the cardiovascular system. Deficiency of cocarboxylase causes an increase in the level of pyruvic and lactic acids in the blood, which leads to acidosis and an acidotic coma.