Active substanceNatamycinNatamycin
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  • Dosage form: & nbsp

    Vaginal suppositories

    Composition:

    1 suppository contains:

    Active substance: natamycin - 100 mg

    Excipients: cetyl alcohol 690 mg, solid fat 700 mg, sorbitan trioleate 460 mg, polysorbate 80 460 mg, sodium hydrogen carbonate 69 mg, adipic acid 64 mg.

    Description:

    Suppressor torpedo form from white with a yellowish tinge to light yellow with a brownish hue.

    Pharmacotherapeutic group:Antifungal agent.
    ATX: & nbsp

    G.01.A.A.02   Natamycin

    Pharmacodynamics:

    Antifungal polyene antibiotic from the macrolide group, which has a wide spectrum of action. It has a fungicidal effect. Natamycin binds the sterols of cell membranes, violating their integrity and function, which leads to the death of microorganisms. Most pathogenic yeast fungi are sensitive to natamycin, especially Candida albicans. Less sensitive to natamycin is dermatophytes.Resistance to natamycin in clinical practice is not found.

    Pharmacokinetics:Natamycin does not have a systemic effect, since it is practically not absorbed from the surface of the mucous membranes.
    Indications:

    Vaginitis, vulvitis, vulvovaginitis caused mainly by fungi Candida.

    Contraindications:

    Hypersensitivity to the components of the drug.

    Carefully:Special precautions when using the drug is not required.
    Pregnancy and lactation:

    The use of Pimafucin® during pregnancy and during lactation is possible.

    Dosing and Administration:

    With vaginitis, vulvitis, vulvovaginitis, one suppository is prescribed per vaginal for 3-6 days. The suppository is inserted into the vagina in the supine position, as deep as possible, once a day at night. With persistent flow of vaginitis caused by Candida albicans, additionally appointed Pimafucin® in the form of tablets for oral administration (1 tablet 4 times a day for 10-20 days) to sanitize the focus of candidiasis infection in the intestine. To treat the candidiasis lesions of the partner's genitals use Pimafucin® in the form of a cream. The duration of the course of treatment is set individually.After the disappearance of the symptoms of the disease is recommended to continue treatment a few more days.

    Precautions for use

    Special precautions when using the drug is not required.

    Side effects:

    Local reactions: possible slight irritation, burning sensation.

    Overdose:

    No cases of an overdose of Pimafucin® have been reported.

    Interaction:

    Drug interaction of the drug Pimafucin® with other drugs is not described.

    Special instructions:

    Suppositories vaginal under the influence of body temperature quickly dissolve, forming a foamy mass, which contributes to a uniform distribution of the active substance.

    In the case of a chronic or recurrent infection, local treatment may be supplemented with the administration of the drug Pimafucin® in tablet dosage form and cream. Cetyl alcohol, which is a part of vaginal suppositories, can cause a slight burning sensation in the genital area with increased sensitivity to this component. During the menstrual period, suppositories are interrupted. During the treatment with suppositories, there is no need to exclude sexual contact.However, it is recommended to conduct a survey of sexual partners and, in the event of a candidiasis lesion, to conduct a course of treatment with Pimafucin®. Also, the use of barrier contraceptives during treatment should be envisaged.

    Effect on the ability to drive transp. cf. and fur:

    Pimafucin® does not affect the ability to drive vehicles and mechanisms.

    Form release / dosage:

    3 suppositories in an aluminum foil strip. 1 or 2 strips together with the instruction in a cardboard bundle.

    Packaging:(1) -packages made of pasteboard (3)
    Packing, non-cellular, contour (2), cardboard
    Storage conditions:

    Store at a temperature not exceeding 25 ° C.

    Keep out of the reach of children.

    Shelf life:

    2 years. Do not use after the expiration date printed on the package.

    Terms of leave from pharmacies:Without recipe
    Registration number:П N013552 / 01
    Date of registration:13.08.2008
    The owner of the registration certificate:Astellas Farma Europe BVAstellas Farma Europe BV Netherlands
    Manufacturer: & nbsp
    Representation: & nbspASTELLAS PHARMA YUROP BV ASTELLAS PHARMA YUROP BV Netherlands
    Information update date: & nbsp23.06.2014
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