Primafungin® (Primafungin®)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceNatamycinNatamycin
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    • Dosage form: & nbspVaginal suppositories
    Composition:

    Composition per 1 suppository: active substance: natamycin - 100 mg;

    Excipients: cetyl alcohol - 690 mg, sorbitan trioleate - 460 mg, polysorbate 80 - 460 mg, sodium hydrogen carbonate - 69 mg, adipic acid - 64 mg, suppository base: semisynthetic glycerides (Suppocyr AM) - a sufficient amount to obtain a suppository with a mass of 2550 mg.

    Description:

    Suppositories cylindrical, from light yellow to yellow or yellow with a cream shade of color. On the cut, an air rod or a funnel-shaped depression is allowed.


    Pharmacotherapeutic group:Antifungal means.
    ATX: & nbsp

    G.01.A.A.02   Natamycin

    Pharmacodynamics:

    Antifungal polyene antibiotic from the macrolide group, which has a wide spectrum of action. It has a fungicidal effect. Natamycin binds the sterols of cell membranes, violating their integrity and function, which leads to the death of microorganisms. Most of the pathogenic yeast fungi are sensitive to natamation, especially the genus Candida. Dermatophytes are less sensitive to natamation. Resistance to natamation in clinical practice is not found.

    Pharmacokinetics:

    Natamycin does not have a systemic effect, since it is practically not absorbed from the surface of the skin and mucous membranes.

    Indications:

    Vaginitis, vulvitis, vulvovaginitis, caused mainly by fungi Candida.

    Contraindications:

    Hypersensitivity to the components of the drug.

    Carefully:not described
    Pregnancy and lactation:

    It is possible to use PRIMAFUNGIN® during pregnancy and lactation.

    Dosing and Administration:

    Intravaginal. In adults and girls (after the initiation of sexual activity) 1 vaginal suppository is used for 3-6 days. The suppository is inserted into the vagina, in the supine position, as deep as possible, once a day at night. Suppositories should not be cut to pieces, since such a change in the storage conditions of the drug may lead to a disruption in the distribution of the active substance.

    If there is no improvement after treatment or new symptoms appear, you should consult your doctor.

    Side effects:

    Local reactions: mild irritation of the mucous membrane of the vagina, burning sensation.

    If any of the side effects indicated in the instructions are aggravated, or if you notice any other side effects not listed in the instructions, inform your doctor.

    Overdose:Currently, cases of overdose of the drug PRIMAFUNING® not reported.
    Interaction:

    Drug interaction of the drug PRIMAFUNING® not described.

    Special instructions:

    Read the instructions carefully before using the product. Keep the manual, it may be needed again.

    If you have any questions, contact your doctor.

    The medicinal product that you are being treated is intended for you personally, and you should not transfer it to others, as it can harm them even if you have the same symptoms as you.

    Vaginal suppositories under the action of body temperature are melted, forming a volumetric spreading foam mass, which promotes a uniform distribution of the active substance along the mucous membrane.

    During the menstrual period, suppositories are interrupted.

    During the period of treatment with suppositories, there is no need to exclude sexual contact. However, it is recommended to conduct a survey of sexual partners and, in case of detection of candidal defeat, to conduct a course of treatment of a partner. Also, the use of barrier contraceptives during treatment should be envisaged.

    Cetyl alcohol, which is a part of vaginal suppositories, can cause a feeling of slight burning in the genital area with increased sensitivity to this component.

    Effect on the ability to drive transp. cf. and fur:

    The drug does not affect the ability to drive vehicles or engage in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

    Form release / dosage:

    Vaginal suppositories, 100 mg.

    Packaging:

    3 suppositories per contour pack of PVC / PE film.

    For 1 or 2 contour mesh packages together with instructions for medical use in a pack of cardboard.
    Storage conditions:Store in a dry, dark place at a temperature of 15 to 25 ° C. Keep out of the reach of children.
    Shelf life:

    2 years.

    Do not use after the expiration date indicated on the packaging.

    Terms of leave from pharmacies:Without recipe
    Registration number:PL-000411
    Date of registration:28.02.2011 / 29.02.2016
    Expiration Date:Unlimited
    The owner of the registration certificate:AVEKSIMA, JSC AVEKSIMA, JSC Russia
    Manufacturer: & nbsp
    FARMAPRIM, LLC The Republic of Moldova
    Information update date: & nbsp16.03.2015
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