Povidone-iodine - instructions for use, dose, side effects, contraindications

active substance: povidone-iodine 0.20 * g (* amount depends on the content of active iodine in the substance povidone-iodine.The content of active iodine should be in the range from 9.0 to 12.0% on a dry basis.);

Excipients: glycerol 85% 0.90 g, macrogol-400 0.90 g, macrogol-4000 1.00 g

Description:

Cone-shaped suppositories of dark brown color, homogeneous structure, with a characteristic odor of iodine.

Pharmacotherapeutic group:antiseptic

ATX: & nbsp

D.08.A.G.02 Povidone-iodine

Pharmacodynamics:

Antiseptic and disinfectant. Gradually released from the complex polyvinylpyrrolidone iodine on contact with skin and mucous membranes, iodine forms with iodine proteins, coagulates them and causes the death of microorganisms. Has a bactericidal effect on Gram-positive and Gram-negative bacteria (with the exception of M. tuberculosis). Effective against fungi, viruses, protozoa.

At the application site, a thin colored layer remains, which is retained until the entire amount of iodine is released.

Pharmacokinetics:

With topical application, there is almost no absorption of iodine from the mucous membrane.

Indications:

Treatment of acute and chronic vaginal infections (vaginitis, vulvovaginitis): bacterial, fungal (caused by Candida albicans), trichomonas Trichomonas vaginalis), viral (including genital herpes), nonspecific, mixed infections.

Prevention of infectious and inflammatory complications before gynecological operations.

Contraindications:

- Hypersensitivity to iodine and other components of the drug;

- pregnancy and lactation;

- dysfunction of the thyroid gland (hyperthyroidism);

- adenoma of the thyroid gland;

- heart failure;

- herpetiform dermatitis of Dühring;

- simultaneous application of radioactive iodine;

- chronic renal failure;

- use of girls to the floor is not recommendedovth maturation

Dosing and Administration:

After preliminary hygienic treatment, 1 suppository (after release from the membrane and previously moistened with water) is inserted deep into the vagina: with acute vaginitis and vulvovaginitis 1-2 times a day for 7 days, with chronic and subacute vaginitis and vulvovaginitis - once a day before going to bed for 14 days (regardless of the phase of the menstrual cycle).

Side effects:

In some cases, local reactions of hypersensitivity to the drug are possible iodine): hyperemia, burning, itching, swelling, pain, which requires withdrawal of the drug. Allergic reactions are possible.

Overdose:

Symptoms: in case of an overdose, excessive absorption of iodine occurs and possible side effects of systemic effects: metabolic acidosis, hyponatremia and renal dysfunction.

Treatment: symptomatic therapy, there is no specific antidote.

Interaction:

Incompatible with other disinfectant and antiseptic agents, especially those containing alkali salts, substances with acid reaction, enzymes and mercury.

In patients undergoing treatment with lithium drugs, the use of povidone-iodine shows a synergistic hypothyroid effect.

Special instructions:

During therapy it is recommended to use sanitary napkins to prevent yellow-brown coloring of the laundry.

Coloring on the skin and tissues is easily washed off with water. After contact with the drug, avoid contact with the product in the eyes.

It is recommended to be careful when introducing virgins.

When using povidone iodine vaginal suppositories for more than 14 days, systemic side effects (metabolic acidosis, hyponatremia, impaired renal and thyroid function) may occur.

When using suppositories, it is possible to damage the condom and diaphragm and reduce their contraceptive effect. It is necessary to recommend to patients the use of additional contraceptive protection during and for at least 5 days after stopping the use of vaginal suppositories.

During the application of Povidone-iodine, indicator papers for the detection of latent bleeding in stool and urine can show false positive results due to the strong oxidative action of povidone-iodine.

In the presence of blood, the bactericidal action may decrease.

It is not recommended to use Povidone-iodine in women who plan pregnancy because of the possible spermatozid effect of povidone-iodine.

Effect on the ability to drive transp. cf. and fur:Povidone-iodine does not impair the ability to drive a vehicle and work with dangerous mechanisms that require increased concentration and speed of psychomotor reactions.

Form release / dosage:Vaginal suppositories, 200 mg.

Packaging:

By 7 suppositories in a contour mesh package made of PVC / PE.

Two contour mesh packages together with instructions for use in a pack of cardboard.

Storage conditions:

Store in the original packaging at a temperature of 0 ° to 25 ° C.

Keep out of the reach of children.

Shelf life:

3 years.

Do not use after the expiry date printed on the package.

Terms of leave from pharmacies:Without recipe

Registration number:П N015048 / 01

Date of registration:07.04.2010

The owner of the registration certificate:Hemofarm ADHemofarm AD Serbia

Manufacturer: & nbsp

HEMOFARM D.O.O. SABAC Serbia

Representation: & nbspHEMOFARM A.D. HEMOFARM A.D. Serbia

Information update date: & nbsp19.08.2015

Illustrated instructions

Instructions

Povidone-iodine (Povidone-iodine)