Povidone-iodine (Povidone-iodine)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substancePovidone-iodinePovidone-iodine
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    • Dosage form: & nbspsolution for external use
    Composition:

    100 ml of the preparation contain:

    active substance: Povidone-iodine 10.00 * g (* - amount depends on the content of active iodine in the substance povidone-iodine.The content of active iodine should be in the range from 9.0 to 12.0% on a dry matter basis);

    Excipients: glycerol 85% 1.500 g, nonoxynol-9 0.312 g, sodium hydrophosphate dodecahydrate 0.320 g, citric acid 0.100 g, sodium hydroxide solution 45% 0.260 g, water purified to 100 ml.

    Description:

    The liquid is dark brown with a characteristic odor of iodine.

    Pharmacotherapeutic group:antiseptic
    ATX: & nbsp

    D.08.A.G.02   Povidone-iodine

    Pharmacodynamics:

    Antiseptic and disinfectant. When released from a complex of iodine with polyvinylpyrrolidone in contact with the skin, iodine forms with iodine proteins, coagulates them, which causes the death of microorganisms. Has a rapid bactericidal effect on Gram-positive and Gram-negative bacteria (with the exception of Mycobacterium tuberculosis). Effective against fungi, viruses, protozoa.

    It has a longer action than the inorganic iodine solution.

    Pharmacokinetics:

    When topical application is almost no absorption of iodine from the surface of the skin and the mucous membrane of the wound.

    Indications:

    - Treatment of bacterial, fungal and viral skin infections;

    - treatment and prevention of wound infections in surgery, traumatology, combustiology;

    - treatment of pressure ulcers, trophic ulcers, diabetic foot;

    - disinfection of patients skin in preparation for surgical interventions, invasive examinations (puncture, biopsy, injection, etc.);

    - disinfection of the skin around drains, catheters, probes.

    Contraindications:

    - Hypersensitivity to iodine and other components of the drug;

    - pregnancy and lactation;

    - dysfunction of the thyroid gland (hyperthyroidism);

    - Thyroid adenoma;

    - heart failure;

    - herpetiform dermatitis of Dühring;

    - simultaneous use of radioactive iodine;

    - chronic renal failure;

    - Children's age up to 2 years.

    Dosing and Administration:

    Outer, adults and children from 2 years.

    For the treatment of the skin, the solution is used undiluted for lubrication, rinsing for 1-2 minutes, then the solution is thoroughly washed off. Povidone-Iodine solution is also used in the form of wet lotions. After application, leave the drug for 2-3 minutes to dry. Repeat the procedure if necessary.

    Side effects:

    In some cases, local reactions of hypersensitivity to the drug are possible (allergic reactions to iodine): hyperemia, burning, itching, swelling, pain, which requires withdrawal of the drug.

    Prolonged use of the drug (more than 7-10 days) and / or large surfaces of the skin, extensive wounds and burns,can cause the phenomenon of iodism ("metallic" taste in the mouth, increased salivation, swelling of the eyes or larynx); systemic reactions (metabolic acidosis, hyponatremia, impaired renal and thyroid function) at the appearance of which, discontinue use of the drug and seek medical attention.

    Overdose:

    Symptoms: with accidental ingestion of iodine, the mucous membrane of the gastrointestinal tract (GIT) may be affected.

    Treatment: gastric lavage with a 0.5% solution of sodium thiosulfate, activated carbon, starch paste, flour, mucous drink, milk and / or intravenously every 4 hours 10 ml of 10% thiosulfate solution, as well as symptomatic therapy, as an antidote.

    Interaction:

    Incompatible with other disinfectant and antiseptic agents, especially containing chlorhexidine, sulfadiazine, alkalis, enzymes, mercury.

    Activity decreases in an acidic environment.

    With simultaneous use with lithium preparations, a synergistic hypothyroid effect is possible.

    The drug Povidone-iodine should not be used in conjunction with drugs containing benzoic acid in its composition because of the possible decrease in pH,as well as with a solution of hydrogen peroxide.

    Special instructions:

    Avoid getting a solution of Povidone-Yoda in the eyes.

    It is necessary in the treatment of bedsores to ensure that under the bed patients there is no excess solution.

    Do not heat before use.

    The presence of blood and pus can reduce the antimicrobial effect of the drug.

    Do not use when biting insects, domestic and wild animals.

    During the application of Povidone-iodine, indicator papers for the detection of latent bleeding in stool and urine can show false positive results due to the strong oxidative action of povidone-iodine.

    At the application site, a colored film is formed that persists until the entire amount of active iodine is released, i. E. its disappearance, means the termination of the drug.

    Coloring on the skin and tissues is easily washed off with water.

    Solution for external use 10% sterile!

    Solutions in packages of 500 ml and 5000 ml are used in hospitals.

    Effect on the ability to drive transp. cf. and fur:

    Povidone-iodine does not impair the ability to drive a vehicle and work with dangerous mechanisms that require increased concentration and speed of psychomotor reactions.

    Form release / dosage:Solution for external use, 10%.
    Packaging:Solution has 3 kinds of consumer packaging.

    For 100 ml of the drug in a bottle of high-density polyethylene with a screw neck with a cap-dropper made of low-density polyethylene, capped with a screw cap made of polypropylene. The bottle together with instructions for use in a pack of cardboard.

    500 ml of the drug in a bottle of high-density polyethylene with a screw neck, sealed with a threaded lid of polypropylene (for hospitals). The instruction for use in a polyethylene bag is attached to the vial.

    For 5000 ml of the drug in a can of high-density polyethylene with a screw neck, ukuporennoy threaded cover of high-density polyethylene with a ring-controlled first opening (for hospitals). The instructions for use in a polyethylene bag are attached to the canister.

    Storage conditions:

    Store in a tightly closed container at a temperature of 0 ° to 25 ° C.

    Keep out of the reach of children.
    Shelf life:

    3 years

    Do not use after the expiration date stated on the package.
    Terms of leave from pharmacies:Without recipe
    Registration number:П N015048 / 04
    Date of registration:27.12.2010
    The owner of the registration certificate:Hemofarm ADHemofarm AD Serbia
    Manufacturer: & nbsp
    Representation: & nbspHEMOFARM A.D. HEMOFARM A.D. Serbia
    Information update date: & nbsp19.08.2015
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