Ringer's solution - instructions for use, doses, side effects, contraindications

Rehydrating agent, has detoxification effect, increases the content of sodium, potassium, calcium and chlorine ions in the blood. When used as a means of replenishing the volume of circulating blood, because of the rapid exit from the bloodstream into the extravasal space, the effect persists for only 30-40 minutes (in connection with which the solution is only suitable for short-term replenishment of the circulating blood volume).

Indications:

Shock, thermal injury (moderate burns and severe burns, frostbites of III-IV degree), acute blood loss; dehydration of II and III degree; intestinal fistula; acute intestinal infections; correction of water and salt balance in acute peritoneal diffusionnite and intestinal obstruction.

Contraindications:Hypersensitivity to drug components, hypervolemia, hypercalcemia, hypernatremia, hyperchloremia; acidosis, oliguria, anuria, decompensated heart failure, cerebral edema, pulmonary edema, concomitant therapy with glucocorticosteroids (risk of hypernatremia).

Carefully:Heart failure, arterial hypertension, impaired liver or kidney function.

Pregnancy and lactation:

During pregnancy are used in cases where the expected benefit to the mother there is a possible risk to the fetus. It should refrain from breastfeeding during the period of use of the drug because of the lack of relevant clinical data.

Dosing and Administration:

The volume of the injected fluid depends on the type of dehydration, the degree of dehydration and the body weight of the patient, the cause of the shock.

Intravenously drip, with speed 60-80 cap / min, with severe disease - 70-90 cap / min or blast.

Daily Adult Dose - 5-20 ml / kg, if necessary, can be increased to 30-50 ml / kg.

Daily dose for children - 5-10 ml / kg, the rate of administration - 30-60 cap / min, with shock dehydration is initially administered 20-30 ml / kg. A course of treatment - 3-5 days.

Side effects:

Hyperhydration, hyperkalemia, allergic reactions.

With the introduction of a large volume of the solution, the development of acidosis is possible.

Overdose:In case of an overdose, a disturbance in the balance of water and electrolytes can occur (hypervolemia, hypernatremia, hyperkalemia, hypercalcemia,hyperchloremia) and acid-base balance. In this case, the drug is immediately discontinued. Symptomatic therapy is performed.

Interaction:

It is possible to increase sodium retention in the body while taking the following medicines at the same time: non-steroidal anti-inflammatory drugs, androgens, anabolic hormones, estrogens, corticotropin, mineralocorticoids, vasodilators or ganglion blockers;

When taken with potassium-sparing diuretics, inhibitors, angiotensin-convertingthe enzyme and potassium preparations increase the risk of hyperkalemia.

In combination with cardiac glycosides, the likelihood of their toxic effects increases.

Special instructions:

In the case of rapid introduction of a large volume and with prolonged use, it is necessary to control the acid-base state and the content of electrolytes. PH change blood, (acidification) leads to a redistribution of potassium ions (lowering the pH leads to an increase in the content of potassium ions in the blood serum).

Due to the high level of chloride ions, long-term use of the drug is not recommended.

Effect on the ability to drive transp. cf. and fur:

Clinical studies to assess the effect of the drug on the ability to manage vehicles and mechanisms were not carried out.

Form release / dosage:

Solution for infusion.

200 ml or 400 ml in a glass bottle, corked with rubber stopper and crimped with an aluminum cap.

250ml and 500ml in a polymer container: A bottle together with instructions for use is placed in a pack of cardboard.

A polymer container with instructions for use is packaged in a secondary bag of film or in a pack of cardboard.

For hospitals: 24, 28 bottles of 200 ml or 12, 15 bottles of 400 ml or 24, 28 containers of 250 ml or 12.15 containers of 500 ml with the instructions for use in an amount equal to the number of packages placed in boxes of cardboard (with gaskets and lattices for bottles).

Storage conditions:

In the dark place at a temperature of no higher than 25 ° C. Do not freeze.

Keep out of the reach of children.

Shelf life:

2 years. Do not use after the expiration date.

Terms of leave from pharmacies:On prescription

Registration number:LP-000668

Date of registration:28.09.2011

The owner of the registration certificate:BIOSINTEZ, PAO BIOSINTEZ, PAO Russia

Manufacturer: & nbsp

BIOSINTEZ, PAO Russia

Information update date: & nbsp21.08.2014

Illustrated instructions

Instructions

Ringer's solution (Ringer solution)