The frequency of the undesirable reactions listed below is represented by the following classification:
Often: ≥10%
Frequently: ≥1% and <10%
Infrequently: ≥0.1% and <1%
Rarely: ≥0.01% and <0.1%
Very rarely: <0.01%
The undesirable phenomena associated with the use of linezolid are usually of mild or moderate severity. Most often, diarrhea, headache and nausea are noted.
Adult patients
From the digestive system: often diarrhea, nausea, vomiting, constipation, abdominal pain (including spastic), candidiasis of the oral mucosa, dyspepsia, changes in the results of functional liver tests; infrequently - change in staining of the tongue and other abnormalities of the tongue, pancreatitis, gastritis, bloating, dry mouth, glossitis, loose stools, stomatitis; rarely - antibiotic-associated colitis, including pseudomembranous colitis, discoloration of the enamel of the teeth.
Laboratory indicators: Increased or decreased potassium or bicarbonate, neutrophilia, eosinophilia, decreased hemoglobin, hematocrit or red blood cell count, an increase or decrease in the number of platelets, leukocytes, an increase in the activity of creatine kinase, an increase in the activity of creatine kinase, an increase in the concentration of glucose on an empty stomach, a decrease in total protein, albumin, sodium or calcium , increased activity of alanine aminotransferase (ALT), aspartate aminotransferase (ACT), alkaline phosphatase (AFP), lactate dehydrogenase (LDH), lipase, amylase; infrequently - leukopenia, neutropenia, thrombocytopenia, hyponatremia, increased concentration of sodium or calcium, reduced fasting glucose concentration, increase in the concentration of total bilirubin, creatinine, increase or decrease in the concentration of chlorine in the blood plasma, increase the number of reticulocytes; rarely - pancytopenia.
From the nervous system: often - insomnia, headache, dizziness, perversion of taste ("metallic" aftertaste); infrequently - cramps, paresthesia, hypoesthesia.
From the sense organs: infrequently - indistinctness of visual perception, tinnitus; rarely - the defect of the fields of view.
From the genitourinary system: often vaginal candidiasis, increased urea blood levels; infrequently - polyuria, renal insufficiency, violations of the vagina and vulva, vaginitis.
From the skin: often - a rash, itching; infrequently - dermatitis, profuse sweating, urticaria.
From the cardiovascular system: often - Increased blood pressure; infrequently - tachycardia, transient ischemic attack, phlebitis, thrombophlebitis.
Other: often - fever, local pain; infrequently - an opportunistic fungal infection, chills, fatigue, thirst.
Children and teens
From the digestive system: often diarrhea, vomiting, nausea, abdominal pain (local and generalized), loose stools, candidiasis of the oral mucosa, gastrointestinal bleeding.
Laboratory indicators: often - thrombocytopenia, anemia, hypokalemia, thrombocytosis, infrequently - eosinophilia, increased triglyceride concentration in the blood, increased activity of ALT, lipase, amylase, increased creatinine concentration and total bilirubin.
From the nervous system: often - headache, vertigo, convulsions.
From the skin: often - a rash, infrequently - a skin itch.
From the respiratory system: often - infections of the upper respiratory tract, pharyngitis, cough, pneumonia, respiratory failure, apnea.
Other: often - fever, pain of unspecified localization, sepsis, generalized edema.
Spontaneous data
Laboratory data: myelosuppression, sideroblastic anemia.
From the sense organs: neuropathy of the optic nerve, change in visual acuity, optic neuritis, loss of vision, change in color vision.
Allergic reactions: anaphylaxis, angioedema, bullous skin lesions similar to Stevens-Johnson syndrome and toxic epidermal necrolysis, alopecia.
From the side of metabolism: lactic acidosis.
From the nervous system: peripheral neuropathy.
Other: serotonin syndrome.