Classification of adverse reactions according to the frequency of development: very often - more than 10%, often - 1-10%, infrequently - 0.1-1%, rarely - 0.01-0.1%, very rarely - less than 0.01%. The undesirable phenomena associated with taking linezolid are usually of mild or moderate severity. Most often, diarrhea, headache and nausea are noted.
Adult patients
From the digestive system: often - diarrhea, nausea, vomiting, constipation, abdominal pain (including spastic), flatulence, candidiasis of the oral mucosa; infrequently, a change in the coloration of the tongue.
Laboratory indicators: often - thrombocytopenia; infrequently - increase concentration of triglycerides in the blood, increased activity of "hepatic" enzymes (including alanine aminotransferase (ALT), aspartate aminotransferase (ACT), alkaline phosphatase (LF), lactate dehydrogenase (LDH), lipase, amylase, total bilirubin and creatinine concentrations), increasing prolactin concentration.
From the nervous system: often - headache, dizziness, convulsions, insomnia; infrequently - a perversion of taste.
From the genitourinary system: often vaginal candidiasis.
From the skin: often - a rash.
Other: often - fever; infrequently an opportunistic fungal infection.
Also were noted: increased blood pressure, dyspepsia, itching.
Adolescents (12 to 17 years of age)
From the digestive system: often - diarrhea, nausea, vomiting, abdominal pain (local and generalized), loose stools.
Laboratory indicators: infrequently - eosinophilia, increased concentration triglycerides in the blood, increased activity of ALT, lipase, creatinine concentration.
From the nervous system: often - headache, vertigo.
From the skin: often - a rash, infrequently - itching.
From the respiratory system: often - infections of the upper respiratory tract, pharyngitis, cough.
Other: often - fever, pain of unspecified localization.
Postmarketing experience.
Laboratory indicators: reversible myelosuppression (thrombocytopenia, anemia, leukopenia, pancytopenia).
From the sense organs: cases of neuropathy of the optic nerve, sometimes leading to loss of vision.
Allergic reactions: anaphylaxis.
From the skin: rash, angioedema; Bullous skin lesions, similar to Stevens-Johnson syndrome.
From the side of metabolism: lactic acidosis.
From the nervous system: peripheral neuropathy, convulsions.
From the digestive system: change in color of tooth enamel.
Other: chills, fatigue, serotonin syndrome.