Frequently: ≥1% and <10%
Infrequently: ≥0.1% and <1%
Rarely: ≥0.01% and <0.1%
Very rarely: <0.01%
Adult patients
The undesirable phenomena associated with the use of linezolid are usually of mild or moderate severity. Most often, diarrhea, headache and nausea are noted.
From the digestive system:
Often: diarrhea, nausea, vomiting, constipation, abdominal pain (including spastic), flatulence, candidiasis of the oral mucosa.
Infrequently: change the coloration of the tongue.
Laboratory indicators:
Often: thrombocytopenia.
Infrequently: an increase in the concentration of triglycerides in the blood, an increase in the activity of "hepatic" enzymes (including alanine aminotransferase (ALT), aspartate aminotransferase (ACT), alkaline phosphatase (LF), lactate dehydrogenase (LDH), lipase, amylase), increasing the concentration of total bilirubin and creatinine, increasing the concentration of prolactin.
From the nervous system:
Often: headache, dizziness, peripheral neuropathy, convulsions (see section "Special instructions").
Infrequently: perversion of taste.
From the central nervous system:
Often: insomnia.
From the genitourinary system:
Often: vaginal candidiasis.
From the skin:
Often: rash.
Other:
Often: fever.
Infrequently: opportunistic fungal infection.
Also were noted: increased blood pressure, dyspepsia, itching.
Children and teens
From the digestive system:
Often: diarrhea, nausea, vomiting, abdominal pain (local and generalized), gastrointestinal bleeding, candidiasis of the oral mucosa, liquid stools.
Laboratory indicators:
Often: thrombocytopenia, anemia, hypokalemia, thrombocythemia.
Infrequently: eosinophilia, an increase in the concentration of triglycerides in the blood, increased activity of ALT, lipase, amylase, the concentration of total bilirubin and creatinine.
From the nervous system:
Often: headache, convulsions (see section "Special instructions"), vertigo.
From the skin:
Often: rash.
Infrequently: itching (not at the injection site).
From the respiratory system:
Often: respiratory depression, apnea, upper respiratory tract infection, pharyngitis, pneumonia, cough.
Other:
Often: fever, sepsis, generalized edema, reactions at the site of administration.
Spontaneous (postmarketing) data.
Laboratory indicators: reversible myelosuppression (thrombocytopenia, anemia, leukopenia, pancytopenia).
From the sense organs: cases of neuropathy of the optic nerve, sometimes leading to loss of vision (see section "Special instructions").
Allergic reactions: anaphylaxis.
From the skin: rash, angioedema; Bullous skin lesions, similar to Stevens-Johnson syndrome.
From the side of metabolism: lactic acidosis.
From the nervous system: peripheral neuropathy, convulsions (see section "Special instructions").
From the digestive system: change in the color of enamel of the teeth (see section "Special instructions").
Other: chills, fatigue, serotonin syndrome (see section "Interaction with other medicinal products" and "Special instructions").