The frequency of unwanted reactions is represented by the following classification:
Very frequent: ≥10%
Frequent: ≥1% and <10%,
Infrequent: ≥0.1% and <1%
Rare: ≥0.01% and <0.1%
Very rare: <0.01%
Adult patients
The undesirable phenomena associated with taking linezolid are usually of mild or moderate severity.Most often, diarrhea, headache and nausea are noted.
From the digestive system:
Frequent: diarrhea, nausea, vomiting, constipation, abdominal pain (including spastic), flatulence, candidiasis of the oral mucosa.
Infrequent: changing the color of the tongue.
Laboratory indicators:
Frequent: thrombocytopenia.
Infrequent: an increase in the concentration of triglycerides in the blood, an increase in the activity of "hepatic" enzymes (including alanine aminotransferase (ALT), aspartate aminotransferase (ACT), alkaline phosphatase (LFG), lactate dehydrogenase (LDH), lipase, amylase, total bilirubin and creatinine concentration) increase in concentration prolactin.
From the nervous system:
Frequent: headache, dizziness, peripheral neuropathy, convulsions (see section "Special instructions").
Infrequent: perversion of taste.
From the central nervous system:
Frequent: insomnia.
From the genitourinary system:
Frequent: vaginal candidiasis.
From the skin:
Frequent: rash.
Other:
Frequent: fever.
Infrequent: opportunistic fungal infection.
Also were noted: increased blood pressure, dyspepsia, itching.
Children and teens
From the digestive system:
Frequent: diarrhea, nausea, vomiting, abdominal pain (local and generalized), gastrointestinal bleeding, candidiasis of the oral mucosa, loose stools.
Laboratory indicators:
Frequent: thrombocytopenia, anemia, hypokalemia, thrombocythemia.
Infrequent: eosinophilia, increased triglyceride concentration in the blood, increased activity of ALT, lipase, amylase, concentration of total bilirubin and creatinine.
From the nervous system:
Frequent: headache, convulsions (see section "Special instructions"), vertigo.
From the skin:
Frequent: rash.
Infrequent: itching (not at the injection site).
From the respiratory system:
Frequent: breathing disorder, apnea, upper respiratory tract infection, pharyngitis, pneumonia, cough.
Other:
Frequent: fever, sepsis, generalized swelling, reactions at the injection site.
Spontaneous (post-marketing) data
Laboratory indicators: reversible myelosuppression (thrombocytopenia, anemia, leukopenia, pancytopenia).
From the sense organs: cases of neuropathy of the optic nerve, sometimes leading to loss of vision (see section "Special instructions").
Allergic reactions: anaphylaxis.
From the skin: rash, angioedema, bullous skin lesions, similar to Stevens-Johnson syndrome.
From the side of metabolism: lactic acidosis.
From the nervous system: peripheral neuropathy, convulsions (see section "Special instructions").
From the digestive system: change in the color of the enamel of the teeth (see the section "Special instructions")
Other: chills, fatigue, serotonin syndrome (see the sections "Interaction with other medicines" and "Special instructions").