Apply cefotaxime intramuscularly and intravenously.
For intramuscular injection dissolve 0.25 or 0.5 g of the drug in 2 ml (respectively 1 g in 4 ml) of sterile water for injection, injected deeply into the gluteal muscle. As a solvent, intramuscular injection also uses 1% lidocaine (for 0.5 g - 2 ml, for 1 g - 4 ml).
For intravenous administration 0.5-1 g of cefotaxime is dissolved in 4 ml (2 g-10 ml) of sterile water for injection. Enter slowly for 3-5 minutes.
For drip administration (within 50-60 minutes) dissolve 2 g of the drug in 100 ml of isotonic sodium chloride solution or 5% glucose solution.
The usual dose of cefotaxime for adults and children over 12 years is 1 g every 12 hours.In severe cases, the dose is increased to 3 or 4 g per day, the drug is administered 3 or 4 times 1 g. The maximum daily dose, depending on the severity of the disease, can be increased to 12 g.
Usual Dose for newborns and children under 12 years of age - 50-100 mg / kg of body weight per day with intervals of administration from 6 to 12 hours. For premature babies, the daily dose should not exceed 50 mg / kg.
In the case of violations of kidney function dose reduced. With a creatinine clearance of 10 mp / min or less, the daily dose of the drug is halved.