Cefotaxime is administered intravenously (jet, drip) or intramuscularly.
Adults and children over 12 years of age (with a body weight of 50 kg or more)
AT table 1 the recommended dose, frequency and route of administration, depending on the type infection.
Table 1
| Type of infection | Daily dose | Single dose, frequency and route of administration |
| Uncomplicated infections of moderate severity | 2.0-6.0 g | 1.0-2.0 g every 8-12 hours intramuscularly or intravenously |
| Infections of severe course | 6.0-8.0 g | 2.0 g every 6-8 h intravenously |
| Life-threatening infections | Up to 12.0 g | 2.0 g every 4-8 h intravenously |
| With uncomplicated gonorrhea | 0.5-1.0 g | 0.5 - 1.0 g once intramuscularly |
The maximum daily dose should not exceed 12.0 g.
Patients with impaired renal function
When the creatinine clearance is less than 20 ml / min / 1.73 m2 the daily dose is recommended to be reduced by 2 times.
Patients on hemodialysis
1.0-2.0 g per day, depending on the severity of the infection. On the day of dialysis, the drug is administered after the procedure.
Children under 12 years old
Newborns, including premature infants At the age of 1 week - 50 mg / kg body weight every 12 hours intravenously. At the age of 1 -4 weeks - 50 mg / kg body weight every 8 hours intravenously. Children from 1 month to 12 years (with a body weight of less than 50 kg)
50-180 mg / kg / day 4 or 6 times a day in equal doses intramuscularly (only for children over 2.5 years old) or intravenously; In severe infection, including meningitis, the daily dose is increased to 100-200 mg / kg / day.
At a body weight of 50.0 kg or more, a dosage for adults is recommended (see Fig. Table 1).
Duration of therapy
It is established individually depending on the type of microorganism, its sensitivity to cefotaxime and the nature of the disease.After temperature normalization or bacteriological confirmation of the eradication of the causative agent, the administration of cefotaxime should be continued for another 2-3 days; for infections caused by beta- hemolytic streptococcus group A, the drug is administered for at least 10 days; it may take several weeks to treat a chronic infection.
Prevention of infection during surgical interventions
Before the surgical operation, 1.0 g of the drug is administered intramuscularly or intravenously before or during anesthesia; at a cesarean section 1,0 g enter intravenously slow (!) immediately after applying the clamps to the umbilical cord.
Further, according to the indications, it is possible to re-administer 1.0 g of the drug intramuscularly or intravenously via 6-12 hours.
Intravenous administration
Streaming
The drug is dissolved in 10 ml of water for injection, as indicated in table 2; injected slowly for 3-5 minutes. The jet preparation should not be administered for less than 3 minutes!
Drip
The drug is dissolved in 50-100 ml of a 0.9% solution of sodium chloride or 5% glucose solution (dextrose), as indicated in Table 2. The duration of the infusion is 50-60 minutes.
As a solvent can not use sodium hydrogen carbonate solution for injection!
Intramuscular injection
The solution is prepared as indicated in Table 2, using water for injection or 1% solution of lidocaine hydrochloride; injected into a relatively large muscle, for example, the upper outer quadrant of the buttocks.
With intramuscular injection, aspiration should be performed to prevent the needle from entering the vessel and to prevent the injection of a solution, especially lidocaine, into the blood!
Preparation of solutions
AT table 2 The volumes of solvent are presented depending on the required dosage and pathway administration, as well as the approximate concentrations of the preparation obtained.
table 2
| Dosage and route of administration | Volume of solvent (ml) | Final volume (ml) | Approximate concentration (mg / ml) |
| Intravenous administration (jet) |
| 500 mg | 10 | 10,2 | 50 |
| 1.0 g | 10 | 10,4 | 95 |
| 2.0 g | 10 | 11,0 | 180 |
| Bnutrient introduction (drip) |
| 1.0 g | 50-100 | 50-100 | 20-10 |
| 1 2.0 g | 50-100 | 50-100 | 40-20 |
| Intramuscular injection |
| 500 mg | 2 | 2,2 | 230 |
| 1.0 g | 3 | 3,4 | 300 |
| 2.0 g | 5 | 6,0 | 330 |
The resulting solution should not contain any foreign mechanical inclusions!