Intramuscularly and intravenously (jet and drip), depending on the chosen dose, the dosage regimen and the severity of the infection.
Adults and children over 12 years of age, or with a body weight of 50 kg or more
When uncomplicated infections are given in / m or / in, 1 g every 12 h.
With uncomplicated acute gonorrhea - 0.5-1 g IM once.
For infections of moderate severity, appoint 1-2 g / m or IV every 8 hours.
In cases where large doses of antibiotic (including for the treatment of sepsis) are required, iv is administered at a dose of 2 g with an interval of 6-8 hours. In life-threatening infections, the intervals between administrations can be reduced to 4 hours (the maximum dose is 12 g / day).
For antimicrobial prophylaxis of postoperative purulent-septic complications, 1.0 g of Cefabol® is administered 30 min before the operation once. If necessary, the administration is repeated at 6 and 12 hours.
In patients undergoing cesarean section, 1.0 g of Cefabol® is administered intravenously immediately after clamping the umbilical cord, then, if necessary, additionally 1 g at 6 and 12 hours after the first dose.
Patients with severe impairment of function kidneys (creatinine clearance 20 ml / min / 1.73 m2) daily dose of Cefabol® is reduced by half.
Children of the first month of life, irrespective of gestational age, use the following dosages: newborns of the first week of life are given IV dose 50 mg / kg every 12 hours; at the age of 1-4 weeks - in / in 50 mg / kg every 8 hours.
In children from 1 month. under 12 years old, or with a body weight of less than 50 kg, the daily dose of Cefabol®, ranging from 50 to 180 mg / kg, is divided by 3-4 in / m or IV. In severe and life-threatening infections, incl.with bacterial meningitis, the dose is increased to 100-200 mg / kg / day and divided by 4-6 IV or IM. Dosages indicated for adults are used in children weighing more than 50 kg.
Rules for the preparation of solutions
To prepare a solution for intravenous injection, 1.0 g of dry sterile Cefabol® powder is dissolved in 3-4 ml of sterile water for injection or 1% of lidocaine solution.
Enter deeply intramuscularly in areas of the body with a pronounced muscular layer (the upper-arm quadrant of the buttock or lateral surface of the thigh).
It is recommended that an aspiration test be carried out to avoid undesirable introduction of the solution into the blood vessel.
To prepare a solution for intravenous administration, 1.0 g of Cefabol® is diluted in 10 ml of sterile water for injection.
Enter iv slowly, for 3-5 min; it is possible to administer through a special node or port for injection of a system for intravenous infusions if the patient receives fluids parenterally.
For intravenous drip injection, 1.0 g of Cefabol® is diluted in 4-5 ml of sterile water for injection. The resulting solution is added to a vial containing 50 or 100 ml of a 5% dextrose solution or 0.9% sodium chloride solution.