Allergic reactions: urticaria, chills or fever, rash, itchy skin, rarely - bronchospasm, eosinophilia, malignant exudative erythema (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome), angioedema, anaphylactic shock.
From the central nervous system: headache, dizziness.
From the urinary system: disturbance of kidney function, oliguria, interstitial nephritis.
From the gastrointestinal tract: nausea, vomiting, diarrhea or constipation, flatulence, abdominal pain, dysbiosis, impaired liver function, rarely - stomatitis, glossitis, pseudomembranous enterocolitis.
From the hematopoiesis: hemolytic anemia, leukopenia, neutropenia, granulocytopenia, thrombocytopenia, agranulocytosis, hypocoagulation.
From the cardiovascular system: potentially life-threatening arrhythmias after a rapid bolus injection into the central vein.
Laboratory indicators: azotemia, increased urea concentration in the blood, increased activity of "liver" transaminases and alkaline phosphatase, hypercreatininemia, hyperbilirubinemia, Coombs positive reaction.
Local reactions: phlebitis, soreness along the vein, soreness and infiltration at the site of intramuscular injection.
Other: superinfection (in particular, vaginal and oral candidiasis).