Bacteriostatic antibiotic of broad spectrum from the group of tetracyclines. Disrupts formation of a complex between transport RNA and ribosome, which leads to repression protein synthesis.
Active against gram-positive microorganisms (Staphylococcus spp. in t.ch. producing penicillinase; Streptococcus spp. (in g.ch. Streptococcus pneumoniae), Haemophilus influenzae, Listeria spp., Bacillus anlhracis and Gram-negative 'microorganisms Neisseria gonorrhoeae. Bordetella pertussis Escherichu coli, Enterobacter spp., Klebsiella spp., Salmonella spp., Shigella spp., and Rickettsia spp., Chlamydia spp., Mycoplasma spp., Treponema spp.
Stable: Pseudomonas aeruginosa, Proteus spp., Serratia spp., most strains Bacteroides spp. and fungi, viruses, beta-hemolytic streptococcus group A (including 44% of strains Streptococcus pyogenes and 74 % strains Streptococcus faecalis).