Tetracycline - instructions for use, dose, side effects, contraindications

Bacteriostatic antibiotic from the group of tetracyclines. It disrupts the formation of a complex between the transport RNA and the ribosome, which leads to suppression of protein synthesis in the microbial cell.

Active with respect to:

- Gram-positive microorganisms: Staphylococcus spp., in t.ch. Staphylococcus aureus, including strains producing penicillinase; Streptococcus pyogenes, Streptococcus pneumoniae (Diplococcus pneumoniae), Bacillus anthracis, Listeria spp.;

- Gram-negative microorganisms: Escherichia coli, Haemophilus influenzae, Haemophilus ducreyi, Klebsiella pneumoniae, Neisseria gonorrhoeae, Bordetella pertussis, Enterobacter spp., Francisella tularensis (Pasteurella pestis), Salmonella spp., Shigella spp.);

- intracellular (intracellular) and other microorganisms: Chlamydia trachomatis, Chlamydia spp., Mycoplasma spp., Rickettsia spp., Treponema spp.

Resistant to tetracycline microorganisms: Pseudomonas aeruginosa, Proteus spp., Serratia spp., most strains Bacteroides spp. and fungi, viruses, beta-hemolytic streptococcus group A (including 44% of strains Streptococcus pyogenes), as well as 74% of strains Enterococcus (Streptococcus) faecalis.

Pharmacokinetics:

With topical application, a therapeutic concentration of tetracycline in the eye tissues is achieved, systemic absorption is low. The path of excretion is through the kidneys and the gastrointestinal tract.

If the corneal epithelium is damaged, the effective concentration of tetracycline in the moisture of the anterior chamber is reached 30 minutes after application.

Indications:

Bacterial (including chlamydial) eye infections caused by microorganisms sensitive to tetracycline - blepharitis, blepharoconjunctivitis, keratitis, keratoconjunctivitis, meibomite (barley), trachoma.

Contraindications:

- Hypersensitivity to the components of the drug;

- impaired liver and kidney function;

- pregnancy;

- the period of breastfeeding;

- children's age till 8 years.

Dosing and Administration:

Locally.

A strip of ointment from 0.5 to 1 cm is placed behind the lower eyelid:

- blepharitis, blepharoconjunctivitis: 3-4 times a day for 5-7 days;

- keratitis, keratoconjunctivitis: 2-3 times a day for 5-7 days. If the condition does not improve during the first 3-5 days of treatment, then a doctor should be consulted;

- meibomite (barley): at night until the symptoms of inflammation disappear;

- trachoma: every 2-4 hours or more often within 1-2 weeks. When the inflammatory process stops, the drug is used 2-3 times a day. The duration of treatment for trachoma should not exceed 1-2 months.

Side effects:Allergic reactions, hyperemia and edema of the eyelids, transient blurring of vision.

Overdose:

When using the drug, an overdose is unlikely.

Interaction:

Not described.

Special instructions:

After the application of the ointment, a transient blurring of vision is possible, therefore during the period of treatment it is not recommended to drive vehicles and work with complex equipment until it is restored.

If the condition does not improve during the first 3-5 days of treatment - you should consult a doctor!

Form release / dosage:Eye ointment, 1%.

Packaging:

By 3, 5 and 10 g in tubes of aluminum with buds screwed on polymeric or tubes laminated with buds screwed polymer.

Each tube together with instructions for use in a pack of cardboard.

Storage conditions:

In the dark place at a temperature of no higher than 15 ° C.

Keep out of the reach of children.

Shelf life:

3 years.

Do not use after the expiration date printed on the package.

Terms of leave from pharmacies:Without recipe

Registration number:LP-004121

Date of registration:06.02.2017

Expiration Date:06.02.2022

The owner of the registration certificate:SYNTHESIS, OJSC SYNTHESIS, OJSC Russia

Manufacturer: & nbsp

SYNTHESIS, OJSC Russia

Representation: & nbspSYNTHESIS JSC Joint-Stock Kurgan Society of Medical Preparations and Products SYNTHESIS JSC Joint-Stock Kurgan Society of Medical Preparations and Products Russia

Information update date: & nbsp02.03.2017

Illustrated instructions

Instructions

Tetracycline (Tetracycline)