Below are the side effects, the frequency of which was estimated as follows: often - more than 1 case for 100 appointments; infrequently - less than 1 case per 100 appointments; rarely - less than 1 case per 1000 appointments.
From the gastrointestinal tract and the hepatobiliary system:
Often: nausea, vomiting, diarrhea, abdominal pain, gastralgia, flatulence. Diarrhea can be a symptom of enterocolitis (which in some cases can be hemorrhagic).
Infrequently: loss of appetite, increased indices of "liver" transaminases and / or bilirubin.
Rarely: possibly development of cholestatitic jaundice, hepatitis, or severe impaired liver function. A rare form of enterocolitis that occurs when using antibiotics is pseudomembranous colitis (in most cases caused by Clostridium difficile). If pseudomembrane colitis is suspected, ofloxacin should be discontinued. Do not use drugs that reduce intestinal peristalsis.
From the central nervous system (CNS):
Often: headache, dizziness, fatigue.
Infrequently: uncertainty of movements, convulsions,psychomotor agitation, phobias, increased intracranial pressure, confusion, disturbed balance, nightmares, anxiety, depression, hallucinations and psychotic reactions, insomnia, unsteady gait and tremor (as a result of muscle coordination disorders), neuropathy, numbness and paresthesia or hyperesthesia.
From the sense organs:
Infrequently: impaired vision, violation of color perception, diplopia, violation of taste and smell (in rare cases, temporary loss of function).
Rarely: hearing loss (including hearing loss). If these reactions were observed in patients after the first dose of ofloxacin, then the course of therapy should be discontinued.
From the side of the cardiovascular system:
Tachycardia and temporary lowering of blood pressure.
Infrequently: a circulatory collapse (as a result of a rapid decrease in blood pressure).
From the hematopoiesis:
Rarely: anemia, leukopenia (including agranulocytosis), thrombocytopenia, pancytopenia, hemolytic and aplastic anemia.
From the urinary system:
Infrequently: impaired renal function.
Rarely: acute interstitial nephritis, or acute renal failure with a progressive increase in serum creatinine concentration. Increase in the content of urea.
Allergic reactions:
Often: skin rash, itching.
Infrequently: photodermatitis, exudative erythema, Stevens-Johnson syndrome, Lyell's syndrome and vasculitis.
Rarely: fever, allergic pneumonitis, allergic nephritis,
bronchospasm, dyspnoea, shock, angioedema, vasculitis-like reactions, eosinophilia, eosinophilic pneumonia.
From the musculoskeletal system:
Rarely: tendonitis, myalgia, arthralgia, tendosinovitis, tendovaginitis, tendon rupture, pain in the muscles and joints (in rare cases, it may be a sign of rhabdomyolysis).
Other side effects:
Rarely: hyper- or hypoglycemia (in patients with diabetes mellitus), weakness, intestinal dysbacteriosis, superinfection, vaginitis.
In some patients (with a particular predisposition), the use of ofloxacin can provoke an attack of porphyria.
Laboratory indicators:
Increased activity of alkaline phosphatase, aspartate aminotransferase, glutamine transaminase and lactate dehydrogenase.