Allergic reactions: skin rash, itching, urticaria, angioedema, allergic nephritis, allergic pneumonitis, eosinophilia, bronchospasm, anaphylactic shock, erythema multiforme exudative (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome), purpura, fever.
From the skin: point hemorrhages (petechiae), dermatitis bullous hemorrhagic, papular rash with cortex, vasculitis.
From the digestive system: gastralgia, abdominal pain, anorexia, nausea, vomiting, diarrhea, flatulence; rarely - hyperbilirubinemia and increased activity of liver transaminases in blood plasma; in isolated cases of hepatitis, cholestatic jaundice. There is a risk of developing pseudomembranous colitis.
From the central nervous system: decreased reaction rate, headache, dizziness, sleep disturbance, general weakness; in some cases, extrapyramidal disorders or other disorders of muscle coordination, tremor, muscle cramps, numbness and paresthesia in the limbs, intense dreams, nightmarish dreams, psychotic reactions in the form of anxiety, arousal, feelings of fear, depressions, confusion, visual and auditory hallucinations, increased intracranial pressure.
From the sense organs: diplopia, violations of color perception, violation of taste, smell, hearing and balance.
On the part of the hematopoiesis system: leukopenia, agranulocytosis, thrombocytopenia, eosinophilia; in isolated cases - hemolytic anemia, pancytopenia, aplastic anemia.
From the urinary system: in some cases - acute interstitial nephritis, hypercreatinemia, increased urea concentration, impaired renal function. From the cardiovascular system: tachycardia, lowering blood pressure.
From the side of the musculoskeletal system: arthralgia, myalgia, tendinitis, tendosynovitis, tendon rupture.
Other: hypoglycemia (in patients with diabetes mellitus), weakness, photosensitivity,
dysbacteriosis, superinfection, vaginitis.