Adaklin - instructions for use, dose, side effects, contraindications

Excipients: methyl dextrose stearate 35 mg, macrogol (20) 35 mg, squalene (natural) 60 mg, methyl parahydroxybenzoate 2 mg, propyl parahydroxybenzoate 1 mg, disodium edetate 1 mg, phenoxyethanol 5 mg, glycerol 30 mg, carbomer (934P) 4 mg, cyclomethicone 130 mg , sodium hydroxide 0.5 mg.

Description:

Homogeneous cream white or almost white.

Pharmacotherapeutic group:Treatment for acne

ATX: & nbsp

D.10.A.D. Preparations for the treatment of acne for external use containing retinoids

D.10.A.D.03 Adapalen

Pharmacodynamics:

The drug is for external use.

Adapalene is a metabolite of the retinoid, has a comedonolytic and anti-inflammatory effect, normalizes the processes of keratinization and epidermal differentiation.

The mechanism of action of adapalene is based on interaction with specific γ-receptors of skin epidermal cells.As a result of the action of adapalene, in particular, the "cohesion" of epithelial cells in the mouth of the sebaceous-hair follicle decreases and the preconditions for the formation of micro-comedones decrease. Adapalen has anti-inflammatory effect in vitro and in vivo, Influencing factors of inflammation by inhibiting migration of leukocytes in the focus of inflammation and the metabolism of arachidonic acid.

Pharmacokinetics:Absorption: absorption of adapalene through the skin is very low (about 4% of the applied dose). Excretion: removal of adapalene from the body occurs mainly with bile.

Indications:Acne.

Contraindications:

pregnancy;

lactation period (breastfeeding);

hypersensitivity to the components of the drug;

children under 12 years;

Carefully:

The drug should be used with caution in dermatitis, eczema, seborrhea.

Pregnancy and lactation:

It is not recommended to use the drug during pregnancy and lactation (breastfeeding).

Dosing and Administration:

Outwardly.

Before applying the cream, it is necessary to clean and dry the skin of the face.With a light touch, evenly apply the cream on the affected surface 1 time / day. before going to bed, avoiding getting the drug on the mucous membranes of the eyes and lips.Therapeutic effect develops after 4-8 weeks of treatment, persistent improvement occurs after 3 months of treatment. In some cases, due to short-term skin irritation, treatment can be suspended until the symptoms of irritation disappear.

Repeated treatment is possible after consultation with a doctor.

Side effects:

Dermatological reactions: skin irritation, flushing and flaking of the skin at the site of application (treatment should be stopped until skin irritation disappears or frequency of application is reduced).

Overdose:

An overdose of the drug is unlikely.

Interaction:

Because the adapalen does not interact with oxygen and does not collapse under the action of light, it is possible to simultaneously treat acne with such drugs as clindamycin or benzoyl peroxide.

Special instructions:

If you accidentally get the drug on the mucous membranes of the eyes, mouth or nose, you must thoroughly wash them with warm water.

Avoid direct sunlight, as skin irritation may occur.Treatment can be continued if solar exposure is minimized through the use of sunglasses and hats.

It is not recommended simultaneous use of cosmetics with drying and irritating effect on the skin (for example, perfume or ethanol containing agents).

Adapalene, applied to the skin in the evening, can be combined with drugs for the treatment of acne, applied in the morning.

Form release / dosage:

Cream for external use 0,1%.

Packaging:

30 grams of cream in an aluminum tube with a latex strip and a protective membrane on hole, with a screw cap having a rod for opening the protective membrane. 1 tube with instructions for use in a cardboard pack.

Storage conditions:

At a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:2 of the year.

Do not use after the expiration date.

Terms of leave from pharmacies:Without recipe

Registration number:LP-001247

Date of registration:21.11.2011/15.08.2016

Expiration Date:21.11.2016

The owner of the registration certificate:San Pharmaceutical Industries Co., Ltd.San Pharmaceutical Industries Co., Ltd. India

Manufacturer: & nbsp

Sun Pharmaceutical Industries, Ltd. India

Representation: & nbspSAN PHARMACEUTICAL INDUSTRIES LTD. SAN PHARMACEUTICAL INDUSTRIES LTD. India

Information update date: & nbsp23.01.2017

Illustrated instructions

Instructions

Adaclin (Adaklin)