Active substanceClotrimazoleClotrimazole
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  • Dosage form: & nbspcream
    Composition:

    100 grams of cream contains: clotrimazole - 1 g and auxiliary substances (petroleum jelly, peach oil, polyethylene oxide 400, emulsifier No. 1, nipagin, nipose, purified water) - up to 100 g.

    Description:The cream is white or almost white.
    Pharmacotherapeutic group:Antifungal agent
    ATX: & nbsp

    G.01.A.F.02   Clotrimazole

    Pharmacodynamics:
    An antifungal agent from the group of imidazole derivatives for external and topical administration reduces the synthesis of ergosterol, which is an integral part of the cell membrane of the microbial wall, and changes the structure and properties of the cell membrane of the microbial wall, which eventually causes lysis of the microbial cell. In small concentrations, it acts fungistatically, and in large concentrations it acts fungicidal, and not only on proliferating cells. In fungicidal concentrations, it interacts with mitochondrial and peroxidase enzymes,resulting in an increase in the concentration of hydrogen peroxide to a toxic level, which also contributes to the destruction of fungal cells. Active against pathogenic dermatophytes (Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis), yeast and mold fungi (genus Candida, Torulopsis glabrata, kind Rhodotorula, Malassezia furfur), causative agents of colored lichen, erythrasms, Gram-positive (Staphylococcus, Streptococcus, Corynebacterium minutissimum) and Gram-negative bacteria (Bacteroides, Gardnerelia vaginalis), Trichomonas vaginalis.
    Indications:

    Fungal lesions of the skin and mucous membranes: dermatomycosis, dermatophytosis, trichophytosis, epidermophytia, microsporia, candidomycosis; interdigital fungal erosion, fungal paronychia; Candidiasis balanitis; pityriasis lichen; erythrasma; Mycoses complicated by secondary pyoderma.

    Contraindications:

    Hypersensitivity, pregnancy (I trimester).

    Dosing and Administration:

    Apply externally and topically. Cream Amicon® is applied a thin layer on the affected skin and mucous membranes 2-3 times a day and gently rubbed. A single dose for a palm-sized surface area is a 5 mm cream column. The course of treatment on average is about 4 weeks, but after it is completed (the disappearance of clinical manifestations) it is advisable to continue using the drug for another 14 days. Duration of therapy of erythrasma is 2-4 weeks, colored lichen - 1-3 weeks.

    Before lubricating the feet wash with warm water and soap, carefully wipe, especially between the fingers. With fungal lesions of the skin of the legs after achieving a therapeutic effect, it is recommended to continue treatment for 2-3 weeks.

    Side effects:

    Perhaps a burning sensation, tingling in the place of application of the cream, the appearance of erythema, blisters, swelling, irritation and flaking of the skin. Allergic reactions (itching, hives).

    Interaction:

    Amphotericin B, nystatin, natamycin reduce the effectiveness of clotrimazole when used simultaneously.

    Form release / dosage:Cream 1%.
    Packaging:

    In tubes of 10, 15, 20 g.

    Storage conditions:

    In a dry place inaccessible to children, at a temperature not exceeding 25 ° C.

    Shelf life:

    2 years. Do not use after the expiration date stated on the package.

    Terms of leave from pharmacies:Without recipe
    Registration number:P N002339 / 01-2003
    Date of registration:17.06.2008
    Expiration Date:Unlimited
    The owner of the registration certificate:NIZHFARM, JSC NIZHFARM, JSC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp05.08.2017
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