Clotrimazole-Teva is a broad-spectrum antifungal agent for external use. The antimycotic effect of the active active agent clotrimazole (imidazole derivative) is associated with impaired synthesis of ergosterol, which is part of the cell membrane of fungi, which changes the permeability of the membrane and causes subsequent lysis of the cell. In low concentrations, it acts fungistatically, and in large concentrations it acts fungicidal, and not only on proliferating cells.In fungicidal concentrations, it interacts with mitochondrial and peroxidase enzymes, resulting in an increase in the concentration of hydrogen peroxide to a toxic level, which also contributes to the destruction of fungal cells.
Effective against dermatophytes, yeast-like and mold fungi, as well as the causative agent of a multicolored lichen Pityriasis versicolor (Malazessia furfur) and the causative agent of erythrasma. Has antimicrobial effect against gram-positive (staphylococcus, streptococcus) and gram-negative bacteria (Bactcroides, Gardnerella vaginalis), as well as in relation to Trichomonas vaginalis.
In vitro in a concentration of 0.5-10 μg / ml clotrimazole suppresses the reproduction of the bacteria of the family Corynebacteria and Gram-positive cocci (with the exception of the utero-cocci) and has a trichomonaside action at a concentration of 100 μg / ml.