Pharmacological action - an antifungal agent of a wide spectrum of action for topical application, antibacterial, antiprotozoal, trihomonatsidnoe. The antimycotic effect of the active active agent clotrimazole (imidazole derivative) is associated with a disruption in the synthesis of ergosterol, which is part of the cobecoming a cell membrane of fungi, what changes membrane permeability and causes subsequent lysis of the cell. In fungicidal concentrations, it interacts with mitochondrial and peroxidase enzymes, resulting in an increase in the neHydrogen to the toxic level, which also contributes to the destruction of fungal cells.
It shows fungicidal and fungistatic activity against dermatomycetes (Trichophyton rubrum. Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis), yeast-like and mold fungi (Candida spp., including Candida albicans, Torulopsis glabrata, kind Rhodotorula, Pityrosporum orbiculare). Active in relation to the pathogen of a multi-colored lichen - Pityrosporum orbiculare (Malassezia furfur). Effective against Gram-positive bacteria - the causative agent of erythrasma Corynebacterium minutissimum, and Staphylococcus spp., Streptococcus spp., gram-negative bacteria - Bacteroides, Gardnerella vaginalis. In high concentrations, it is active in relation to Trichomonas vaginalis.