Clotrimazole is a broad-spectrum antifungal agent for external use. The antimycotic effect of clotrimazole (an imidazole derivative) is associated with a disruption in the synthesis of ergosterol, which is part of the cell membrane of fungi, which changes permeability, membranes, and causes subsequent cell lysis. In small concentrations, it acts fungistatically, and in large concentrations it acts fungicidal, and not only on proliferating cells.In fungicidal concentrations, it interacts with mitochondrial and peroxidase enzymes, resulting in an increase in the concentration of hydrogen peroxide to a toxic level, which also contributes to the destruction of fungal cells.
Effective against dermatophytes, yeast-like and mold fungi,] as well as the causative agent of multi-colored lichen Pityriasis versicolor (Malassezia furfur).