Clotrimazole (Clotrimazole)

Clotrimazole is a derivative of imidazole. Antifungal means of a wide spectrum of action. The effect of the drug is associated with a violation of the synthesis of ergosterol, which is part of the cell membrane of fungi, which causes a change in its structure and properties, and leads to lysis of the cell. At concentrations of 1 μg / ml in vitro and more than 6 μg / ml in vivo Clotrimazole acts fungistatically. At concentrations of more than 10 μg / ml has fungicidal effect on most species of fungi, not only on proliferating cells.In a relationship Candida has a fungicidal effect at concentrations of 2 μg / ml and above. In fungicidal concentrations, it interacts with mitochondrial and peroxidase enzymes, resulting in an increase in the concentration of hydrogen peroxide to a toxic level, which also contributes to the destruction of fungal cells.

It is active against pathogenic dermatophytes (Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis), yeast and mold fungi (Candida spp., Torulopsis glabrata, Rhodotorula, Pityrosporum orbiculare), as well as the causative agent Pityriasis versicolor (varicoloured varicella) and the causative agent of erythrasms .

Has antimicrobial effect against Gram-positive (Staphylococcus, Streptococcus) and Gram-negative bacteria (Bacteroides, Gardnerella vaginalis), as well as against Trichomonas vaginalis, Malazessia furfur (causative agent Pityriasis versicolor) and Corynebacterium minussimum (causative agent of erythrasms).