Active substanceNicotinoyl gamma-aminobutyric acidNicotinoyl gamma-aminobutyric acid
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  • Dosage form: & nbspsolution for intravenous and intramuscular administration
    Composition:

    Active substance: N- nicotinoyl-gamma-aminobutyric acid sodium salt - 50 or 100 g; Excipients: solution of hydrochloric acid 0.1 M to pH 6.7 to 8.0; water for injection -1 l.

    Description:Transparent colorless or slightly colored liquid.
    Pharmacotherapeutic group:Nootropic remedy
    ATX: & nbsp

    N.06.B.X   Other psychostimulants and nootropic drugs

    Pharmacodynamics:

    Nootropic agent, dilates the vessels of the brain. It also has a tranquilizing, psychostimulating, antiaggregant and antioxidant effect. Improves the functional state of the brain due to the normalization of tissue metabolism and influence on cerebral circulation (increases the volume and linear speed of cerebral blood flow,reduces the resistance of cerebral vessels, suppresses platelet aggregation, improves microcirculation).

    At the course reception increases physical and mental efficiency, reduces headache, improves memory, normalizes sleep; contributes to the reduction or disappearance of feelings of anxiety, tension, fear; improves the condition of patients with motor and speech disorders.

    Pharmacokinetics:

    Absorption is fast and complete in any way of administration. Penetrates through the hemoencephalic barrier, is retained for a long time in the tissues of the body. Bioavailability is 50-88%. It is excreted mainly by the kidneys in unchanged form. The half-life of the drug is 0.51 h.

    Indications:

    Cerebrovascular insufficiency, vegetative-vascular dystonia, asthenia, depressive disorders in old age.

    Conditions, accompanied by anxiety, fear, increased irritability, emotional lability. Asthenic conditions caused by various neuropsychic diseases.

    As part of a comprehensive treatment - for the management of acute alcohol intoxication; with chronic alcoholism - to reduce asthenic, asthenic-neurotic, postpsychotic, pre-recurrent conditions,as well as alcoholic encephalopathy. As part of complex therapy - migraine (prevention), craniocerebral trauma, Neuroinfection.

    Improving the portability of physical and mental loads (to persons who are in tense and extreme conditions of activity, to restore the physical performance of athletes, to increase resistance to physical and mental stress).

    Open angle glaucoma (for stabilization of visual function)

    In urological practice (in children older than 3 years and in adults with disorders of urination) to improve the adaptive function of the bladder (reducing detoxification hypoxia).

    Contraindications:

    Hypersensitivity, chronic renal failure, pregnancy, lactation. Children under 3 years.

    Dosing and Administration:

    Intravenous drip or jet (slow), intramuscularly.

    Before the drip introduction, the contents of the ampoule are dissolved in 200 ml of a 0.9% solution of isotonic sodium chloride. With chronic disorders of cerebral circulation - in / in or / m, at 100 mg - 200 mg, once a day for 10 days in / in, then in / m. The course of treatment is 15-30 days. When the condition improves, they switch to oral administration.

    When cerebrovascular diseases in adolescence, the daily dose - 50 mg - 150 mg. Repeated course in 10-15 days.

    As an anti-asthenic and anxiolytic agent - 100-200 mg for 10-15 days.

    With alcoholism during the withdrawal period - 100-150 mg / day, a short course of 6-7 days, with more persistent violations outside of the abstinence, I / in and / m, daily dose - 50-100 mg / day for 10-15 days .

    To stop acute uncomplicated intoxication with ethanol as part of complex therapy, inject at a saturating dose of 5 mg / kg and a maintenance dose of 1.56 mg / kg / h in a volume of 2.5 liters of the infusion solution, for 4 hours, in the morning and in the evening.

    For the treatment of glaucoma - 100-200 mg IM for 10 days.

    For restoration of working capacity and at the raised loadings - adults on 200 mg / day during 10-15 days, athletes - 200 mg for 2 weeks of training period.

    Children from 3 to 10 years - 100 mg IM for 10 days, children from 11-15 to 200 mg for 10 days.

    Side effects:

    Irritability, agitation, anxiety, dizziness, headache, nausea, allergic reactions (skin rash, itching), lowering blood pressure.

    Overdose:

    Symptoms: increased severity of adverse reactions.

    Treatment: symptomatic.

    Interaction:Shortens the action of barbiturates, enhances the action of narcotic analgesics.
    Effect on the ability to drive transp. cf. and fur:
    Form release / dosage:

    Solution for intravenous and intramuscular injection 50 and 100 mg / ml.

    Packaging:2 ml per ampoule of neutral glass. 10 ampoules are placed in a box of cardboard. 5 ampoules per contour cell pack. 1, 2 contour packs are placed in a pack of cardboard. By 5, 10 ampoules per pack of cardboard with partitions or lattices, or
    separator of cardboard or paper sack. In each pack and box, insert the instructions for use and a knife for opening ampoules or a ceramic ampoule scarifier. When you use ampoules with notches, rings and dots, the ampoule opener or the ampoule ceramic scapegrator is not inserted.
    Storage conditions:

    List B. In a dry, protected from light, out of reach of children, at a temperature of no higher than 25 ° C.

    Shelf life:

    3 years. After the expiration date, the drug should not be used.

    Terms of leave from pharmacies:On prescription
    Registration number:LSR-000120/09
    Date of registration:14.01.2009 / 12.10.2015
    Expiration Date:Unlimited
    The owner of the registration certificate:BIOCHEMIST, OJSC BIOCHEMIST, OJSC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp07.08.2017
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