Active substanceNicotinoyl gamma-aminobutyric acidNicotinoyl gamma-aminobutyric acid
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  • Dosage form: & nbsppills
    Composition:

    Active substance: picamilon (N - nicotinoyl γ-aminobutyric acid sodium salt), calculated on the active substance, 0.01 g; 0.02 g; 0.05 g.

    Excipients: potato starch, milk sugar (lactose), microcrystalline cellulose, calcium stearate, impellose, talc.

    Description:Tablets are white or white with a grayish hue of color, round, biconvex.
    Pharmacotherapeutic group:Nootropic remedy
    ATX: & nbsp

    N.06.B.X   Other psychostimulants and nootropic drugs

    Pharmacodynamics:

    Nootropic agent, dilates the vessels of the brain. It also has a tranquilizing, psychostimulating, antiaggregant and antioxidant effect. Improves the functional state of the brain due to the normalization of tissue metabolism and effects on the brainblood circulation (increases volumetric and linear speed of cerebral blood flow, reduces the resistance of cerebral vessels, suppresses platelet aggregation, improves microcirculation, including in the retina). Stimulates metabolism in the nervous tissue, has antihypoxic activity. With the course of admission increases physical and mental performance, reduces headache, improves memory; normalizes sleep, helps reduce or disappear feelings of anxiety, stress, fear (has a tranquilizing effect without muscle relaxation, lethargy, drowsiness); improves the condition of patients with motor and speech disorders.

    Pharmacokinetics:

    Quickly absorbed from the gastrointestinal tract. It penetrates the blood-brain barrier, it is distributed in the brain, kidneys, muscles and adipose tissue, and it is retained for a long time in the tissues of the body. Bioavailability is 50-88%. Virtually not metabolized, excreted mainly by the kidneys in unchanged form, half-life of the drug (T1/2) - 0.51 h.

    Indications:

    In adults:

    Cerebrovascular insufficiency, vegetative-vascular dystonia, asthenia, depressive disorders in old age.

    Conditions accompanied by anxiety, fear, increased irritability, emotional lability (as part of complex therapy). Asthenic conditions caused by various neuropsychic diseases.

    In chronic alcoholism - to reduce asthenic, asthenoneurotic, postpsychotic, prerepidive states, as well as alcoholic encephalopathy.

    In the complex therapy - migraine (prevention), craniocerebral trauma, neuroinfection.

    Improving the portability of physical and mental loads (to persons who are in tense and extreme conditions of activity, to restore the physical performance of athletes, to increase resistance to physical and mental stress).

    Primary open-angle glaucoma (for stabilization of visual function).

    Have children over 3 years of age and adults with disorders of urination:

    In urological practice to improve the adaptive function of the bladder (reduction of detrusor hypoxia).

    Contraindications:

    Hypersensitivity, kidney disease (acute, chronic), pregnancy, lactation, children under 3 years. It is not recommended for acute disturbance of cerebral circulation.

    Since the preparation contains lactose: lactase insufficiency, lactose intolerance, glucose malabsorption / galactose syndrome.

    Pregnancy and lactation:Contraindicated.
    Dosing and Administration:

    Inside, regardless of food intake.

    In cerebrovascular diseases, a single dose of 0.02-0.05 g 2-3 times a day, a daily dose of 0.06-0.15 g. The course of treatment -1-2 months. Repeated course - after 5-6 months. Depressive states of late age - 0.04-0.2 g / day in 2-3 doses, the optimal interval - 0.06-0.12 g / day, for 1.5-3 months. To restore efficiency and with increased loads - 0,06-0,08 g / day for 1-1,5 months, for athletes in the same dose, within 2 weeks of the training period.

    As anti-asthenic and anxiolytic drug - 0,04-0,08 g / day, if necessary - up to 0,2-0,3 g / day, for 1-1,5 months.

    Preventing a migraine attack - 0.05 g 3 times a day.

    At alcoholism during the period of abstinence - 0,1-0,15 g / day, short course 6-7 days; with more persistent violations outside of abstinence - a daily dose of 0.04-0.0 g for 4-5 weeks. Primary open angle glaucoma: 0.05 g 3 times a day - 1 month.

    Urologic dysfunction: for children: functional urination disorder - 3-10 years 0.04 g / day, over 10 years 0.06 g / day in 2-3 doses; with myelodysplasia children under 10 years 0.06 g / day,11-15 years 0.1 g / day in 3 divided doses; adults - 0.15 g / day in 3 divided doses, course 1 month.

    Side effects:

    Irritability, agitation, anxiety, dizziness, headache, nausea, allergic reactions (skin rash, itching).

    Overdose:

    Symptoms: increased severity of adverse reactions.

    Treatment: symptomatic.

    Interaction:Shortens the action of barbiturates, enhances the action of narcotic analgesics.
    Form release / dosage:

    Tablets of 10 mg, 20 mg and 50 mg.

    Packaging:

    For 60 tablets of 10 mg or 20 mg or 30 tablets of 20 mg or 50 mg in cans of glass with a triangular corolla, or 60 tablets of 50 mg or 100 tablets of 10 mg or 20 mg in cans of glass with a triangular corolla.

    For 60 tablets of 50 mg or 100 tablets of 10 mg or 20 mg in cans of polymeric.

    For 10 tablets in a contour mesh box made of polyvinylchloride film and aluminum foil printed lacquered.

    Each jar, 5 or 10 contour packs, together with the instruction for use, is placed in a pack of chromium-ersatz or cardboard cardboard.

    Storage conditions:

    In a dry, protected from light place at a temperature of no higher than 25 ° C. In a place inaccessible to children.

    Shelf life:3 years.Do not use after the expiration date printed on the package.
    Terms of leave from pharmacies:On prescription
    Registration number:LSR-004428/09
    Date of registration:04.06.2009 / 02.10.2015
    Expiration Date:Unlimited
    The owner of the registration certificate:BIOCHEMIST, OJSC BIOCHEMIST, OJSC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp07.08.2017
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