Nicotinoyl gamma-aminobutyric acid - instructions for use, dose, side effects, contraindications

The main brake mediator of the central nervous system. Strengthens energy processes, increases oxygen consumption of tissues, normalizes blood supply, promotes the utilization of glucose in the brain. Improves thinking, dynamics of nervous processes in the brain, memory, promotes recovery of motor activity and speech after cerebral circulation disorders, has a mild psycho-stimulating effect.

A nicotinic acid

Is a substrate for the synthesis of nicotinadenine nucleotide (NAD-codeegirdase I) and nicotinadenine nucleotide phosphate (NADP-codeogirdase II), which accept and transfer protons in oxidation-reduction reactions, providing all types of exchange, including energy. It improves nitrogen and carbohydrate metabolism, provides tissue respiration.

It has a vasodilating effect, improves microcirculation, manifests fibrinolytic activity by decreasing platelet aggregation. Has hypolipidemic activity, lowers the cholesterol / phospholipids in hypercholesterolemia.

Pharmacokinetics:

After ingestion, up to 88% is absorbed in the gastrointestinal tract. It is distributed in the tissues of the brain, kidneys, muscles and fat stores, for a long time it is kept in the body. Penetrates through blood-brain and placental barriers.

It is not metabolized.

The half-life is 50 minutes. Elimination of the kidneys in an unchanged form.

Indications:

It is used for cerebrovascular insufficiency, asthenic syndrome, vegetative-vascular dystonia, depressive disorders in old age. Used as part of complex therapy for the relief of acute alcohol intoxication, with migraine, nephroinfection, craniocerebral trauma.

In order to stabilize the visual function is used for glaucoma. To improve the adaptive function of the bladder by reducing hypoxia detrusor is used in urological practice in adults and children older than 3 years.

Used to increase the endurance of mental and physical intense and extreme conditions of activity, as well as to restore physical performance and increase resistance to mental stress.

ICD-10

V.F30-F39.F33 Recurrent depressive disorder

V.F30-F39.F31.5 Bipolar affective disorder, the current episode of severe depression with psychotic symptoms

V.F30-F39.F31 Bipolar affective disorder

V.F20-F29.F25.9 Schizoaffective disorder, unspecified

V.F20-F29.F21 Chrysotile disorder

V.F00-F09.F06.9 Mental disorder due to brain damage or dysfunction or somatic disease, unspecified

V.F40-F48.F48.0 Neurasthenia

VI.G40-G47.G43 Migraine

XIV.N30-N39.N31.9 Neuromuscular dysfunction of urinary bladder, unspecified

VI.G90-G99.G93.4 Encephalopathy, unspecified

XXI.Z70-Z76.Z73.0 Overwork

XXI.Z70-Z76.Z73.3 Stress condition, not elsewhere classified

Contraindications:

Chronic renal failure, individual intolerance of the components of the drug.

Carefully:

Acute disturbance of cerebral circulation.

Pregnancy and lactation:

Recommendations for FDA - category is not defined. No studies have been conducted. Contraindicated during pregnancy and lactation.

Dosing and Administration:

Inside, regardless of the time of food intake by 0,02-0,05 g 2-3 times / day.

Parenteral: intravenously drip on 200 ml of 0.9% solution of sodium chloride to 0.1-0.2 g.

The highest daily dose: 0.8 g.

The highest single dose: 0.2 g.

Side effects:

Central and peripheral nervous system: irritability, anxiety, drowsiness, headache.

Digestive system: nausea.

Allergic reactions.

Overdose:

Increased side effects.

Treatment is symptomatic.

Interaction:

Shortens the time of action of barbiturates and narcotic analgesics.

Special instructions:

When the drug is prescribed for the purpose of arresting a migraine, it is necessary to use a combination with β-adrenoreceptor blockers and psychotropic drugs.

Instructions

Nicotinoyl gamma-aminobutyric acid (Acidum nicotinoyl-gamma-aminobutyricum)