Frequency of adverse reactions according to the WHO classification: very often (≥10%), often (≥1% and <10%), infrequently (≥0.1% and <1%), rarely (≥0.01% and <0.1%), very rarely (<0.01%), including individual reports.
From the central and peripheral nervous system: often - increased fatigue, dizziness, headache, drowsiness; infrequent - malaise, fainting, asthenia, hypoesthesia, paresthesia, peripheral neuropathy, tremor, insomnia, emotional lability, unusual dreams, nervousness, depression, anxiety; rarely - apathy, agitation, loss of consciousness; very rarely - ataxia, amnesia, migraine.
From the cardiovascular system: often - peripheral edema (ankles and feet), a feeling of palpitations, a feeling of heat and a "tide" of blood to the face; infrequently - excessive reduction of blood pressure, orthostatic hypotension, vasculitis; very rarely - development or aggravation of heart failure; heart rhythm disturbances (extrasystole, bradycardia, ventricular tachycardia and fibrillation or atrial flutter), myocardial infarction, chest pain.
From the digestive system: often - abdominal pain, nausea; infrequent - vomiting, constipation, flatulence, indigestion, diarrhea, anorexia, dryness of the oral mucosa; rarely - gingival hyperplasia,increased appetite; very rarely - gastritis, pancreatitis, hyperbilirubinemia, jaundice (usually cholestatic), increased activity of "hepatic" transaminases, hepatitis.
From the genitourinary system: infrequent - frequent urination (pollakiuria), painful urge to urinate, nocturia, violation of sexual function (including decreased potency); very rarely - dysuria, polyuria.
From the musculoskeletal system: infrequently - arthralgia, muscle cramps, myalgia, back pain, arthrosis; rarely - myasthenia gravis.
From the skin: infrequently - alopecia; rarely - dermatitis, very rarely - xeroderma, a violation of skin pigmentation.
On the part of the hematopoiesis system: very rarely - thrombocytopenic purpura, leukopenia, thrombocytopenia.
From the respiratory system: infrequently - shortness of breath, rhinitis; very rarely - cough.
Allergic reactions: infrequently - itchy skin, rash (including erythematous, maculopapular rash); very rarely - angioedema, erythema multiforme, urticaria.
Other: infrequent - "ringing" in the ears, gynecomastia, weight gain / decrease, vision impairment, diplopia, accommodation disorder, xerophthalmia,conjunctivitis, pain in the eyes, a violation of taste sensations, chills, nosebleeds; very rarely - parosmia, "cold" sticky sweat, hyperglycemia, increased sweating, thirst.