The incidence of adverse reactions listed below was determined according to the following (World Health Organization classification): very often - not less than 10%; often - not less than 1%, but less than 10%; infrequently - not less than 0,1%, but less than 1%; rarely - not less than 0.01%, but less than 0.1%; very rarely - less than 0.01%, including individual reports.
Co cardiovascular system: often - peripheral edema (ankles and feet), a feeling of palpitations, a sensation of heat and a "tide" of blood to the skin of the face; infrequently - excessive reduction of blood pressure, orthostatic hypotension, vasculitis; rarely - development or exacerbation of heart failure; very rarely - shortness of breath, heart rhythm disturbances (including bradycardia, ventricular tachycardia and atrial fibrillation), myocardial infarction, chest pain, pulmonary edema.
From the central nervous system: often - headache (especially at the beginning of treatment), dizziness,increased fatigue, drowsiness; infrequent - general malaise, hypoesthesia, asthenia, paresthesia, tremor, insomnia, emotional lability, unusual dreams, nervousness, depression, increased sweating; rarely - convulsions, vertigo, fainting, apathy, agitation; very rarely - ataxia, amnesia.
From the digestive system: often - nausea, pain in the abdomen; infrequent - vomiting, flatulence, constipation or diarrhea, dryness of the oral mucosa, thirst; rarely - gingival hyperplasia, increased appetite; very rarely - pancreatitis, gastritis, jaundice (usually cholestatic), increased activity of "liver" transaminases, hepatitis.
From the hematopoiesis: very rarely - leukopenia, thrombocytopenia.
From the genitourinary system: infrequently - pollakiuria, painful urge to urinate, nocturia, a violation of sexual function (including a decrease in potency); very rarely - dysuria, polyuria.
From the respiratory system: infrequently - shortness of breath, rhinitis; very rarely - cough, nosebleeds.
From the musculoskeletal system: infrequently - myalgia (with prolonged use), arthralgia, back pain, arthrosis; rarely - myasthenia gravis.
From the skin: rarely - dermatitis; very rarely - alopecia, xeroderma, purpura, cold sticky sweat, a violation of skin pigmentation.
Allergic reactions: rarely - skin itching, rash (including erythematous, maculopapular rash); very rarely - hives, angioedema, erythema multiforme.
From the sense organs: infrequent - ringing in the ears, impaired vision, diplopia, accommodation disorder, xerophthalmia, conjunctivitis, pain in the eyes, perversion of taste; very rarely - parosmia.
From the side of metabolism: very rarely - hyperglycemia.
Other: infrequently - weight loss, weight gain, chills.