Side effects on the frequency of occurrence are distributed as follows: very often (≥ 10%), often (≥ 1% and <10%), sometimes (≥ 0.1% and <1%), rarely (≥ 0.01% and <0.1%), very rarely, including individual reports (<0.01%).
From the cardiovascular system: often - peripheral edema (swelling of the ankles and feet), palpitations, "hot flashes" of blood to the skin of the face, marked decrease in blood pressure; very rarely - syncope, dyspnea, vasculitis. Some adverse effects noted in individual patients can not be differentiated from the symptoms of the natural course of the underlying disease: myocardial infarction, arrhythmias (including ventricular tachycardia and atrial fibrillation), chest pain.
From the musculoskeletal system: sometimes - arthralgia, muscle cramps, myalgia, back pain, arthrosis; rarely - myasthenia gravis.
From the central and peripheral nervous system: often - increased fatigue, dizziness, headache, drowsiness; sometimes - general malaise, fainting, increased sweating, asthenia, hypoesthesia, paresthesia, peripheral neuropathy, tremor, insomnia, mood lability, unusual dreams, nervousness, depression, anxiety; rarely - cramps, apathy, agitation; very rarely - ataxia, amnesia, migraine.
From the digestive system: often - abdominal pain, nausea; sometimes - vomiting, constipation, flatulence, dyspepsia, diarrhea, anorexia, dry mouth, thirst; rarely - gingival hyperplasia, increased appetite; very rarely - gastritis, pancreatitis, hyperbilirubinemia, jaundice (usually cholestatic), increased activity of "hepatic" transaminases, hepatitis.
On the part of the hematopoiesis system: very rarely - thrombocytopenic purpura, leukopenia, thrombocytopenia.
From the side metabolism: very rarely - hyperglycemia.
On the part of the respiratory system: sometimes shortness of breath, rhinitis; very rarely - cough.
From the urinary system: sometimes - frequent urination, painful urination, nocturia, impotence; very rarely - dysuria, polyuria.
Allergic reactions: pruritus, rash (including erythematous, maculopapular rash, urticaria), angioedema, erythema multiforme.
Other: sometimes - alopecia, ringing in the ears, gynecomastia, weight gain / increase, vision impairment, diplopia, accommodation disorder, xerophthalmia, conjunctivitis, eye pain, taste distortion, chills, nosebleeds; rarely - dermatitis; very rarely - parosmia, xeroderma, a violation of pigmentation, increased sweating.