The frequency of adverse reactions listed below was determined according to the following (classification of the World Health Organization): very often - not less than 10%; often - not less than 1%, but less than 10%; infrequently - not less than 0,1%, but less than 1%; rarely - not less than 0.01%, but less than 0.1%; very rarely - less than 0.01%, including individual reports.
From the central nervous system - often - headache (especially at the beginning of treatment), dizziness, fatigue, drowsiness; infrequent - general malaise, hypoesthesia, asthenia, paresthesia, peripheral neuropathy, tremor, insomnia, emotional lability, unusual dreams, nervousness, increased excitability, depression, anxiety, increased sweating; rarely - cramps, apathy, agitation; very rarely - ataxia, amnesia, migraine.
From the digestive system: often - nausea, pain in the abdomen; infrequently - vomiting, anorexia, dryness of the oral mucosa, thirst; rarely - gingival hyperplasia, increased appetite; very rarely - pancreatitis, gastritis, jaundice (usually cholestatic), hyperbilirubinemia, increased activity of "hepatic" transaminases, hepatitis.
From the cardiovascular system: often - peripheral edema (ankles and feet), palpitations, "hot flashes" of blood to the skin of the face; infrequently - excessive reduction of blood pressure, orthostatic hypotension, vasculitis; rarely - development or aggravation of the course of CHF; very rarely - fainting, shortness of breath, heart rhythm disturbances (including bradycardia, ventricular tachycardia and atrial fibrillation), myocardial infarction, pain in a difficult cage, pulmonary edema.
From the hematopoietic and lymphatic systems: rarely - thrombocytopenic purpura, leukopenia, thrombocytopenia.
From the stroma of the urinary system: infrequently - pollakiuria, painful urge to urinate, nocturia; very rarely - dysuria, polyuria.
From the country of the reproductive system and mammary glands: infrequently - gynecomastia, impotence.
From the respiratory system: infrequently - shortness of breath, rhinitis; very rarely - cough.
From the musculoskeletal system: infrequently - muscle cramps, myalgia, arthralgia, back pain, arthrosis; rarely - myasthenia gravis.
From the skin: infrequently - alopecia; rarely - dermatitis; very rarely - alopecia, xeroderma, cold sticky sweat, a violation of skin pigmentation.
Allergic reactions: rarely - skin itching, rash (including erythematous, maculopapular rash); very rarely - hives, angioedema, muliform erythema.
From the sense organs: infrequent - ringing in the ears, impaired vision, diplopia, disruption of accommodation, xerophthalmia, conjunctivitis, pain in the eyes; very rarely - parosmia.
From the side of metabolism: very rarely - hyperglycemia.
Other: infrequently - weight loss, weight gain, taste distortion, epistaxis, chills.