Ampiox® (Ampiox®)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceAmpicillin + OxacillinAmpicillin + Oxacillin
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  • Ampiox®
    capsules inwards 
    BRYNTSALOV-A, CJSC     Russia
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    powder w / m in / in 
    BRYNTSALOV-A, CJSC     Russia
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    powder w / m 
    BRYNTSALOV-A, CJSC     Russia
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    SYNTHESIS, OJSC     Russia
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    • Dosage form: & nbspcapsules
    Composition:

    Per one capsule:

    0.125 g ampicillin trihydrate (in terms of ampicillin),

    0,125 g of oxacillin sodium salt (in terms of oxacillin).

    Excipients: potato starch, sugar (sucrose), talc, magnesium stearate, impellose.

    Capsule composition: gelatin, titanium dioxide.

    Description:Capsules of white color number 0. The contents of the capsules are granules of white or almost white color.
    Pharmacotherapeutic group:Antibiotic combined (semi-synthetic penicillins)
    ATX: & nbsp

    J.01.C.R.50   Combinations of penicillins

    Pharmacodynamics:

    Combined antibiotic, combining the spectrum of action of ampicillin and oxacillin.

    Ampicillin - semi-synthetic penicillin, acts bactericidal, acid-fast. Active against gram-positive, non-retentive penicillinase (Staphylococcus spp., Streptococcus spp., Streptococcus pneumoniae) and gram-negative (Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Salmonella spp., Shigella spp., Proteus mirabilis, Haemophilus influenzae, Haemophilus influenzae) microorganisms.

    Oxacillin - penicillin-resistant semisynthetic antibiotic from the penicillin group, acid-fast; has bactericidal action against gram-positive microorganisms (Staphylococcus spp., Streptococcus spp., in t.ch. Streptococcus pneumoniae, Actinimyces spp., Bacillus anthracis, Corynebacterium diphtheriae, anaerobic spore-forming sticks, incl. Clostridium), Gram-negative cocci (Neisseria gonorrhoeae, Neisseria meningitidis), E.coli, Pr.mirabilis, H.influenzae, K.pneumoniae, Actinomyces spp, Treponema spp.

    Pharmacokinetics:

    Both antibiotics are excreted by the kidneys, partly with bile.

    When repeated injections are not cumulated.

    Indications:

    Bacterial infections caused by susceptible pathogens: sinusitis, tonsillitis, otitis media; bronchitis, pneumonia; cholangitis, cholecystitis; pyelonephritis, pyelitis, cystitis, urethritis, gonorrhea, cervicitis; infections of the skin and soft tissues: erysipelas, impetigo, secondarily infected dermatoses, etc.

    Prevention of postoperative complications during surgical interventions (including against the background of immunodeficiency), infections in newborns (infection of the amniotic fluid, impaired breathing of the newborn, requiring the use of resuscitative measures, the risk of aspiration pneumonia).

    Severely leaking infections (sepsis, endocarditis, meningitis, postpartum infection).

    Contraindications:

    Hypersensitivity, infectious mononucleosis, lymphocytic leukemia.

    Carefully:Children born to mothers with hypersensitivity to penicillins.
    Pregnancy and lactation:

    Possible use in pregnancy according to indications.

    It is excreted in breast milk in low concentrations. If you need to use the drug during lactation, you should decide whether to stop breastfeeding.

    Dosing and Administration:

    Inside.

    Single dose for adults and children over 14 years is 0.5-1 g, daily - 2-4 g. Children 3-7 years - 100 mg / kg / day, 7-14 - 50 mg / kg / day. Duration of treatment - from 5-7 days to 2 weeks. The daily dose is divided into 4-6 receptions.

    Side effects:

    Allergic reactions: urticaria, skin hyperemia, Quincke's edema, rhinitis, conjunctivitis; fever, arthralgia, eosinophilia, in rare cases anaphylactic shock; superinfection, dysbacteriosis, taste change, vomiting, nausea, diarrhea, rarely pseudomembranous enterocolitis, leukopenia, neutropenia, anemia.

    When signs of anaphylactic shock appear, urgent measures must be taken to remove the patient from this condition: the introduction of epinephrine, glucocorticosteroids (hydrocortisone or prednisolone) and antihistamines, if necessary, carry out artificial ventilation of the lungs.

    Interaction:

    Antacids, glucosamine, laxatives, food, aminoglycosides - slow down and reduce absorption; ascorbic acid increases the absorption of the drug.

    Bactericidal antibiotics (including aminoglycosides, cephalosporins, vancomycin, rifampicin) have a synergistic effect; bacteriostatic drugs (macrolides, chloramphenicol, lincosamides, tetracyclines, sulfonamides) - antagonistic.

    Increases the effectiveness of indirect anticoagulants (suppressing the intestinal microflora, reduces the synthesis of vitamin K and prothrombin index); reduces the effectiveness of oral contraceptives, drugs, in the process of metabolism which produces paraaminobenzoic acid, ethinyl estradiol - the risk of bleeding "breakthrough".

    Diuretics, allopurinol, phenylbutazone, non-steroidal anti-inflammatory drugs, probenecid - reducing tubular secretion, increase the concentration of the drug in the plasma, which increases the risk of toxic effects.

    Allopurinol increases the risk of skin rash.

    Special instructions:

    At course treatment by a preparation it is necessary to spend the control of a condition of functions of bodies of a hemopoiesis, a liver and kidneys.

    The possibility of developing superinfection (due to the growth of insensitive microflora) requires a corresponding change in antibacterial therapy.

    In patients who are hypersensitive to penicillins, there may be cross-allergic reactions with cephalosporin antibiotics.

    When using high doses in patients with renal insufficiency, a toxic effect on the central nervous system is possible.

    Form release / dosage:

    Capsules 250 mg (0.125 g ampicillin and 0.125 g oxacillin).

    Packaging:

    For 20 capsules in a can of orange glass or in a can of glass.

    20 capsules in a polymer can.

    10 capsules in a planar cell package. Bank or 1, 2 contoured cells with instructions for use - in a pack of cardboard.
    Storage conditions:

    List B. In a dry, the dark place at a temperature of no higher than 25 ° C. Keep out of the reach of children.

    Shelf life:2 years. Do not use after the expiration date.
    Terms of leave from pharmacies:On prescription
    Registration number:P N003911 / 01
    Date of registration:16.02.2010
    Expiration Date:Unlimited
    The owner of the registration certificate:BRYNTSALOV-A, CJSC BRYNTSALOV-A, CJSC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp19.08.2017
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