Oxamp - instructions for use, dose, side effects, contraindications

Active substanceAmpicillin + OxacillinAmpicillin + Oxacillin

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Dosage form: & nbspcapsules

Composition:

Composition per one capsule:

Active substances: Ampicillin trihydrate (in terms of ampicillin) -125 mg, Oxacillin sodium (in terms of oxacillin) -125 mg.

Excipients: potato starch, sucrose (sugar powder).

The composition of the gelatin capsule: titanium dioxide, methyl parahydroxybenzoate, propyl parahydroxybenzoate, acetic acid, gelatin.

Description:Capsules of white color number 0. Contents of the capsules are white granules with a yellowish tint of color.

Pharmacotherapeutic group:Antibiotic combined (semi-synthetic penicillins)

ATX: & nbsp

J.01.C.R.50 Combinations of penicillins

Pharmacodynamics:

Combined antibiotic, combining the spectrum of action of ampicillin and oxacillin.

Ampicillin - semi-synthetic penicillin, acts bactericidal, acid-fast. It is active against Gram-positive, non-forming penicillinase, (Staphylococcus spp., Streptococcus spp., Streptococcus pneumoniae) and gram-negative (Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Salmonella spp., Shigella spp., Proteus mirabilis, Haemophilus influenzae) microorganisms.

Oxacillin - penicillin-resistant semisynthetic antibiotic from the penicillin group, acid-fast; has bactericidal action against gram-positive microorganisms (Staphylococcus spp., Streptococcus spp., in t.ch. Streptococcus pneumoniae, Actinimyces spp., Bacillus anthracis, Corynebacterium diphtheriae, anaerobic spore-forming sticks, incl. Clostridium spp.), Gram-negative cocci (Neisseria gonorrhoeae, Neisseria meningitidis), Escherichia coli, Proteus mirabilis, Haemophilus influenzae, Klebsiella pneumoniae, Actinomyces spp., Treponema spp. The action of the drug is stable Pseudomonas aeruginosa and others non-fermenting gram-negative bacteria, most strains Proteus vulgaris, Providencia rettgeri, Morganella morganii.

Pharmacokinetics:The drug penetrates well into the blood when ingested. Maximum concentrations of the drug in the blood are detected after 1.5 -2 hours after ingestion. Both antibiotics are excreted by the kidneys, in part - with bile. When repeated injections are not cumulated.

Indications:

Infectious-inflammatory diseases caused by microorganisms sensitive to the preparation: sinusitis, tonsillitis, otitis media; bronchitis, pneumonia; cholangitis, cholecystitis; pyelonephritis, pyelitis, cystitis, urethritis, gonorrhea, cervicitis; infections of the skin and soft tissues: erysipelas, impetigo, secondarily infected dermatoses.

Contraindications:

Hypersensitivity, infectious mononucleosis, lymphocytic leukemia, children under 3 years (for this dosage form).

Carefully:

Children born to mothers with hypersensitivity to penicillins.

Pregnancy and lactation:

The use of the drug during pregnancy is possible only if the intended benefit for the mother exceeds the potential risk to the fetus.

If it is necessary to prescribe the drug during lactation, breastfeeding should be stopped (it is excreted in breast milk).

Dosing and Administration:

Inside.

Doses of the drug, indicated below, are the sum of dosages of ampicillin and oxacillin in their fixed ratio of 1: 1,

A single dose for adults and children over 14 years is 0.5-1 g, daily - 2-4 g.

Children 3-7 years - 100 mg / kg / day, 7-14 years - 50 mg / kg / day. The daily dose is divided into 4-6 receptions. Duration of treatment - from 5-7 days to 2 weeks.

Side effects:

Allergic reactions: urticaria, skin hyperemia, angioedema, rhinitis, conjunctivitis; fever, arthralgia, eosinophilia, in rare cases - anaphylactic shock.

From the gastrointestinal tract: dysbacteriosis, taste change, vomiting, nausea, diarrhea, rarely - pseudomembranous enterocolitis.

From the hematopoiesis: leukopenia, neutropenia, anemia.

Other: superinfection.

Overdose:

Symptoms: increased severity of side effects.

Treatment: gastric lavage, reception of activated charcoal, symptomatic therapy.

Interaction:

Antacids, glucosamine, laxatives, food, aminoglycosides (with enteral administration) slow down and decrease absorption; ascorbic acid increases absorption.

Bactericidal antibiotics (including aminoglycosides, cephalosporins, vancomycin, rifampicin) have a synergistic effect; bacteriostatic medicinal products (macrolides, chloramphenicol, lincosamides, tetracyclines, sulfonamides) - antagonistic.

Increases the effectiveness of indirect anticoagulants (suppressing the intestinal microflora, reduces the synthesis of vitamin K and prothrombin index); reduces the effectiveness of oral contraceptives, drugs, in the process of metabolism of which the formation of paraminobenzoic acid, ethinyl estradiol - the risk of bleeding "breakthrough".

Diuretics, allopurinol, tubular secretion blockers, phenylbutazone, non-steroidal anti-inflammatory drugs and other medications,blocking tubular secretion, increase the concentration of the drug in the plasma, which increases the risk of developing toxic effects.

Allopurinol increases the risk of skin rash.

Special instructions:

With prolonged treatment, it is necessary to monitor the status of the function of the organs of hematopoiesis, liver and kidneys.

The possibility of developing superinfection (due to the growth of insensitive microflora) requires a corresponding change in antibacterial therapy.

At the appearance of signs of anaphylactic shock, urgent measures should be taken to remove the patient from this condition: the introduction of epinephrine, glucocorticosteroids and antihistamines, if necessary, carry out artificial ventilation of the lungs.

In patients who are hypersensitive to penicillins, there may be cross-allergic reactions with cephalosporin antibiotics.

When used in high doses in patients with renal insufficiency, a toxic effect on the central nervous system is possible.

Form release / dosage:

Capsules 125 mg + 125 mg.

Packaging:

10 capsules in a planar cell package.

1, 2 contour mesh packages with instructions for use are placed in a pack of cardboard.

Storage conditions:

List B. In a dry, protected from light place, at a temperature of no higher than 20 ° C.

Keep out of the reach of children.

Shelf life:

2 years. Do not use after the expiration date.

Terms of leave from pharmacies:On prescription

Registration number:P N002258 / 01

Date of registration:22.10.2008

Expiration Date:Unlimited

The owner of the registration certificate:SYNTHESIS, OJSC SYNTHESIS, OJSC Russia

Manufacturer: & nbsp

SYNTHESIS, OJSC Russia

Information update date: & nbsp23.05.2017

Illustrated instructions

Instructions

Oxamp® (Oxamp®)