Andipal Avexima - instructions for use, dose, side effects, contraindications

Active substanceBendazole + Metamizol sodium + Papaverine + PhenobarbitalBendazole + Metamizol sodium + Papaverine + Phenobarbital

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ASFARMA, LLC Russia

Dosage form: & nbspPills.

Composition:Active substances: metamizole sodium (analgin) 250 mg, phenobarbital 20 mg, bendazole (dibazol) 20 mg, papaverine hydrochloride 20 mg.

Excipients: starch-starch - 46 mg, talc - 7 mg, acid stearic - 3 mg, calcium stearate - 4 mg.

Description:

Tablets white or white with a weak yellow shade of color, flat-cylindrical with a facet and a risk.

Pharmacotherapeutic group:Analgesic agent (analgesic non-narcotic agent + antispasmodic drug + barbiturate).

ATX: & nbsp

N.02.B.B.52 Metamizole sodium in combination with other drugs, excluding psycholeptics

Pharmacodynamics:

Combined drug. The combination of the components of the drug leads to a mutual enhancement of their pharmacological action.

Metamizole sodium - a derivative of pyrazolone, has an analgesic and antipyretic effect.

Bendazol (dibasol) - a vasodilating agent; has a vasodilating effect, stimulates the function of the spinal cord. Has direct spasmolytic effect on smooth muscles of blood vessels and internal organs. It facilitates synaptic transmission in the spinal cord.

Papaverina hydrochloride is an antispasmodic, has hypotensive effect, reduces tone and relaxes smooth muscles of internal organs and vessels. Phenobarbital, in small doses has a sedative effect and enhances the effect of other components.

Indications:

Pain syndrome (mild or moderate) with spasms of smooth muscles of internal organs: renal colic, biliary colic, intestinal colic; biliary dyskinesia, postcholecystectomy syndrome; spasm of ureters and bladder; algodismenorea.

Spasm of cerebral vessels, migraine.

As an auxiliary drug: pain syndrome after surgical intervention and diagnostic procedures.

Contraindications:

Hypersensitivity (including the derivatives of pyrazolone); oppression of bone marrow hematopoiesis; marked hepatic and / or renal insufficiency; deficiency of glucose-6-phosphate dehydrogenase; Children under the age of 8, pregnancy, lactation period, tachyarrhythmias, severe angina, collapse, decompensated chronic heart failure; angle-closure glaucoma; hyperplasia of the prostate; intestinal obstruction, megacolon.

Dosing and Administration:

Inside, adults and children older than 8 years, 1 tablet 2-3 times a day.

The duration of the application without consulting a doctor should not exceed 7 days.

Side effects:

Allergic reactions.

From the central nervous system: drowsiness, decreased speed psychomotor reactions.

From the gastrointestinal tract: nausea, constipation.

From the cardiovascular system: arterial hypotension ..

With prolonged use: leukopenia, agranulocytosis, impaired liver and kidney function.

Interaction:

Combination with nitrates (nitroglycerine, nitrosorbide, joint to others), calcium channel blockers (nifedipine, Corinfar, etc.), beta-blockers (anaprilin, metoprolol, talinolol and others), ganglion blockers (pentamine, etc.), diuretics (furosemide, hypothyroid, etc.), myotropic antispasmodics (dipyridamole, eufillin, etc.) enhances the hypotensive effect of these drugs.

Simultaneous use with other non-narcotic analgesics can lead to mutual enhancement of toxic effects.

Joint application with adsorbents, astringents and enveloping agents reduces the absorption of the drug in the gastrointestinal tract.

Special instructions:

At long (more than 7 days) application control of a picture of peripheric blood and a functional status of a liver is necessary.

If there is no effect within 3 days, stop taking the drug and consult a doctor.

For children and adolescents under 18, the drug should be used only as directed by the doctor.

Effect on the ability to drive transp. cf. and fur:During treatment it is necessary to refuse employment by potentially dangerous kinds of activity,requiring increased concentration of attention and speed of psychomotor reactions.

Form release / dosage:Pills.

Packaging:

For 10 tablets in a contour mesh or cell-free packaging; 1 or 2 contour squares in a pack of cardboard with instruction for

medical application, contour non-jawed packages with an equal number of instructions for medical use are placed in a group package.

Storage conditions:

In a dry place, protected from light and inaccessible to children.

Shelf life:

2 years and 6 months. The drug should not be used after the expiration date.

Terms of leave from pharmacies:Without recipe

Registration number:LSR-002455/08

Date of registration:03.04.2008

The owner of the registration certificate:ASFARMA, LLC ASFARMA, LLC Russia

Manufacturer: & nbsp

ASFARMA, LLC Russia

Information update date: & nbsp27.06.2014

Illustrated instructions

Instructions

Andipal Avexima (Andipal Avexima)