Combination with nitrates (nitroglycerine, nitrosorbide, suture, etc.), blockers of Ca-channels (nifedipine, Corinfar, etc.), beta-blockers (anaprilin, metoprolol, talinolol and others), ganglion blockers (pentamine, etc.), diuretics (furosemide, hypothiazide, etc.), myotropic antispasmodics (dipyridamole, eufillin, etc.) enhances the hypotensive effect of the drug.
Simultaneous use with other non-narcotic analgesics can lead to mutual enhancement of toxic effects.
Joint application with adsorbents, astringents and enveloping agents reduces the absorption of the drug in the gastrointestinal tract.