The frequency of these side effects is indicated in accordance with the WHO classification: very often - more than 10%; often more than 1% and less than 10%; infrequently - more than 0, 1% and less than 1%; rarely - more than 0.01% and less than 0.1%; very rarely - less than 0, 01%, including individual cases: the frequency is unknown - according to available data, it was not possible to establish the frequency of occurrence.
For Andipal:
To date, no side effects have been reported with this combination. The frequency of occurrence of the following possible side effects is unknown.
From the central nervous system: drowsiness, decreased speed of psychomotor reactions.
From the digestive system: nausea, constipation.
From the side of the cardiovascular system: arterial hypotension.
Allergic reactions:
With prolonged use: leukopenia, agranulocytosis, impaired liver and kidney function.
For Metamizol sodium:
From the skin: infrequent - persistent drug rash; rarely - a rash (eg, maculopapular); very rarely - Stevens-Johnson syndrome, toxic epidermal necrolysis.
From the urinary system: very rarely - acute renal dysfunction, which in very rare cases can lead to proteinuria, oligo- or anuria and acute renal failure, acute interstitial nephritis.
On the part of the organs of hematopoiesis: rarely - leukopenia; very rarely - agranulocytosis, including cases with fatal outcome, thrombocytopenia; frequency unknown - aplastic anemia, pancytopenia, including fatal cases. *
* These reactions may occur, even if earlier metamizol sodium did not cause complications. There are a number of signs of increased risk of agranulocytosis, if metamizol sodium apply more than one week. This reaction is dose-independent and may occur at any time during treatment. It is manifested by high fever, chills, sore throat, pain when swallowing, inflammation of the mucous membranes of the mouth, nose, throat, genital and anal area. However, with the use of antibiotics, these phenomena may be mild. There is a slight increase in lymph nodes and spleen, or it is completely absent. The sedimentation rate of erythrocytes is significantly increased, the content of granulocytes is sharply reduced or they are not determined. As a rule, but normal hemoglobin, erythrocyte and platelet counts are not always preserved. Tactics of treatment implies immediate withdrawal of the drug, that is, the drug should be canceled immediately, without waiting for the results of laboratory tests, if an unexpected deterioration in the general condition occurs, fever does not subside, or new or painful ulceration on the mucous membranes, especially in the mouth, nose or throat.If pancytopenia occurs, the drug should be immediately discontinued and the general blood test should be monitored before returning to normal.
From the side of the cardiovascular system: infrequently - isolated decline arterial pressure (possibly pharmacologically conditioned and not accompanied by other manifestations of anaphylactic / anaphylactoid reactions). Reduction of blood pressure can be pronounced. With fever, a dose-dependent sharp drop in blood pressure is also possible without other signs of a hypersensitivity reaction.
Allergic reactions: rarely - anaphylactoid or anaphylactic reactions; ** very rarely - analgesic bronchial asthma. In patients with analgesic bronchial asthma, intolerance is usually manifested by attacks of bronchial asthma; frequency unknown - anaphylactic shock. **
** These reactions are especially characteristic for parenteral administration of metamizole sodium, can be severe and endanger life, in some cases, lead to death. These reactions can occur even if earlier metamizol sodium did not cause complications.These reactions may occur during administration or immediately after swallowing or develop several hours later. However, they predominantly occur within the first hour after application. In more mild cases, they are manifested by rashes on the skin and mucous membranes (for example, itching, burning, redness, blisters and swelling), shortness of breath and, more rarely, gastrointestinal disorders. In severe cases, these mild reactions can be transformed into generalized urticaria, severe angioedema (including the larynx), severe bronchospasm, cardiac arrhythmias, arterial hypotension (in some cases it is preceded by an increase in blood pressure), shock. In this regard, at the first signs of skin reactions the drug should be discarded.
Other: frequency unknown - reported on staining of urine in red, which may be due to the presence of rubric acid in low concentrations (Metamizol sodium metabolite).
For Phenobarbital:
From the central nervous system: frequency unknown - asthenia, dizziness, general weakness, ataxia, nystagmus, paradoxical reaction (especially in elderly and weakened patients - arousal), hallucinations, depression, nightmarish dreams, syncope.
From the digestive system: the frequency is unknown - vomiting, with prolonged use of a violation of liver function.
On the part of the organs of hematopoiesis: frequency unknown - agranulocytosis, megaloblastic anemia, thrombocytopenia.
Allergic reactions: frequency unknown - skin rash, hives, swelling of the eyelids, face and lips, shortness of breath, rarely - exfoliative dermatitis, malignant exudative erythema (Stevens-Johnson syndrome).
Other: frequency unknown - with prolonged use of drug dependence.
For Bendazole:
The listed effects are manifested when applied in large doses. When the dose is lowered or the drug is withdrawn, these side effects quickly disappear.
From the central nervous system: frequency unknown - dizziness, headache.
From the skin: frequency unknown - increased sweating.
From the digestive system: frequency is unknown - nausea.
For Papaverine hydrochloride:
From the central nervous system: often - drowsiness.
From the skin: often - skin rash (usually erythematous, urticaria), infrequently - itchy skin, rarely - excessive sweating.
From the digestive system: often - nausea, constipation, infrequently - increased activity of "liver" transaminases.
From the cardiovascular system: often - lowering blood pressure, infrequently - ventricular extrasystole.
On the part of the organs of hematopoiesis: very rarely - eosinophilia.