Antiflu® Cilds (Antiflu® Kid's)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceParacetamol + Chlorfenamine + Ascorbic acidParacetamol + Chlorfenamine + Ascorbic acid
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    BAYER, AO     Russia
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    • Dosage form: & nbspPowder for solution for oral administration
    Composition:

    For one sachet:

    Active substances:

    paracetamol (acetaminophen) 160 mg,

    ascorbic acid 50 mg,

    chlorpheniramine maleate 1 mg.

    Auxiliary substances: citric acid 50 mg, dye Red charming 0.05 mg, raspberry flavor 100 mg, silicon dioxide colloid (siloid) 4 mg, silicon dioxide 20 mg, sodium citrate dihydrate 2 mg, corn starch 1 mg, powdered sugar 2794, 95 mg, sucrose 8800 mg, titanium dioxide 1 mg, calcium phosphate 1 mg.

    Description:

    White or white with a yellowish tinge loose powder, including crystalline particles, with the smell of raspberry.

    Description of the solution after dissolution: opaque solution of light pink color with the smell of raspberry.

    Pharmacotherapeutic group:ARI and "colds" of symptoms remedy (analgesic non-narcotic means + H1-histamine receptor blocker + vitamin)
    ATX: & nbsp

    N.02.B.E.51   Paracetamol in combination with other drugs, excluding psycholeptics

    Pharmacodynamics:

    Combined drug with vitamin C and raspberry flavor. Paracetamol (acetaminophen) has an analgesic and antipyretic effect. Ascorbic acid (vitamin C) increases the body's resistance to infections, improves the tolerability of paracetamol. Chlorpheniramine maleate has an anti-allergic effect, eliminates a runny nose, watery eyes, itchy eyes and nose. Quickly removes fever, headache and muscle pain, sore throat, runny nose.

    Indications:

    Symptomatic treatment of ARVI, including influenza and "colds" in children from 2 to 12 years, accompanied by fever, chills, body aches, headache and muscle pain, sore throat, runny nose, nasal congestion, lacrimation, sneezing.

    Contraindications:

    Hypersensitivity to individual components of the drug, expressed violations of the liver and kidneys, zakratougolnaya glaucoma, prostatic hypertrophy, sugar deficiency / isomaltase, fructose intolerance, glucose-galactose malabsorption, children under 2 years.

    Carefully:

    Carefully apply for: arterial hypertension, severe cardiovascular diseases, diabetes mellitus, bronchial asthma, chronic obstructive pulmonary disease, thyrotoxicosis, pheochromocytoma, difficulty urinating with prostate adenoma, blood diseases, congenital hyperbilirubinemia (Gilbert syndrome, Dubin-Johnson and Rother syndrome), progressive malignant diseases, viral hepatitis, hyperoxalaturia, deficiency of glucose-6-phosphate dehydrogenase.

    Pregnancy and lactation:

    Not recommended for use during pregnancy and during breastfeeding.

    Dosing and Administration:

    Inside.

    A single dose for children 2-5 years is the contents of 1 sachet, for children 6-12 years old - the contents of 2 sachets.

    Take inside, regardless of food intake, previously dissolving the contents of the package in 150 ml of warm water. If necessary, repeat the reception every 4-6 hours, but not more than 3 doses during the day. If the temperature does not decrease, the pain, chills, runny nose do not stop - always consult a doctor. The total duration of treatment should not exceed 5 days.

    Side effects:

    Allergic reactions: skin rash, itching, urticaria, toxic epidermal necrolysis (Dyel's syndrome), polymorphiform erythema (Stevens-Johnson syndrome), acute generalized exanthematous pustulosis, angioedema (Quincke's edema), anaphylactic shock.

    From the central nervous system: dizziness, sleep disturbance (drowsiness), headache, excitability, decreased speed of psychomotor reactions, feeling tired.

    On the part of the hematopoiesis system: anemia, thrombocytopenia, thrombocytopenic purpura, leukopenia, pancytopenia, agranulocytosis, hemolytic anemia, methemoglobinemia.

    From the digestive system: nausea, vomiting, stomach discomfort, abdominal pain, diarrhea. Disturbances from the liver and bile ducts: liver damage (increased activity of "liver" enzymes), hepatitis, as well as dose-dependent hepatic insufficiency, liver necrosis. Prolonged unjustified use can lead to liver fibrosis, liver cirrhosis.

    From the urinary system: urinary retention, with prolonged use of high doses of nephrotoxic action.

    Disturbances from the respiratory organs: bronchospasm or exacerbation of bronchial asthma, including in patients susceptible to acetylsalicylic acid or other NSAIDs.

    Other: mydriasis, paresis of accommodation, increased intraocular pressure.

    Overdose:

    If an overdose occurs, seek medical help immediately.

    Paracetamol

    Symptoms: diarrhea, decreased appetite, nausea and vomiting, abdominal discomfort and / or abdominal pain, increased sweating. The clinical picture of acute paracetamol overdose develops within 6-14 hours after paracetamol administration. Symptoms of chronic overdose appear after 2-4 days after increasing the dose of the drug. In case of severe poisoning, severe hepatic insufficiency may develop, including hepatic encephalopathy, coma, and death. Hypokalemia and metabolic acidosis (including lactic acidosis) can also develop in conditions of acute and / or chronic overdose. Frequent clinical manifestations after 3-5 days are jaundice, fever, liver odor from the mouth, hemorrhagic diathesis, hypoglycemia, hepatic insufficiency.Acute renal failure with acute tubular necrosis, which is diagnosed by severe pain in the lumbar region, hematuria and proteinuria, can develop without a serious impairment of liver function.

    Treatment: gastric lavage, Activated carbon in the first 6 hours, the introduction of donors of SH-groups and precursors of the synthesis of glutathione-methionine in 8-9 hours after an overdose and N-acetylcysteine ​​after 12 hours.

    Chlorfeniramine

    Symptoms: dizziness, agitation, sleep disturbances, depression, convulsions and coma.

    Treatment: symptomatic.

    Ascorbic acid

    High doses of ascorbic acid (more than 3000 mg) can cause temporary osmotic diarrhea and impairment of the gastrointestinal tract, such as nausea, discomfort in the stomach.

    Treatment: symptomatic, forced diuresis.

    Interaction:

    It is not recommended to take concomitantly with sleeping pills, sedatives and preparations containing alcohol.

    Increases the concentration in the blood of benzyl-penicillin and tetracyclines. Improves absorption in the intestines of iron preparations (converts trivalent iron into bivalent); can increase the excretion of iron with simultaneous use with deferoxamine.Increases the risk of developing crystalluria in the treatment of salicylates and sulfonamides short-acting, slows the excretion of acids by the kidneys, increases the excretion of drugs that have an alkaline reaction (including alkaloids), reduces the concentration of oral contraceptives in the blood. Increases the total clearance of ethanol. With simultaneous use reduces the chronotropic effect of isoprenaline. Reduces the therapeutic effect of antipsychotic drugs (neuroleptics) - derivatives of phenothiazine, tubular reabsorption of amphetamine and tricyclic antidepressants. Reduces the effectiveness of uricosuric medicines.

    Can both increase and decrease the effect of anticoagulant drugs. Paracetamol (or its metabolites) interacts with enzymes involved in vitamin K-dependent synthesis of coagulation factor. Interactions between paracetamol and warfarin or coumarin derivatives may lead to an increase in the international normalized ratio (INR) and an increased risk of bleeding. Patients taking oral anticoagulants should not take long paracetamol without medical supervision.

    Ethanol enhances the sedative effect of chlorphenamine. Antidepressants, anti-Parkinsonian and phenothiazine antipsychotic drugs increase the risk of side effects (urinary retention, dryness of the oral mucosa, constipation). Glucocorticosteroids increase the risk of developing glaucoma.

    Inductors of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites of paracetamol, which makes it possible to develop severe hepatotoxic reactions even with a slight overdose. Inhibitors of microsomal oxidation (incl. cimetidine) reduce the risk of hepatotoxic effects of paracetamol.

    Diflunisal increases the plasma concentration of paracetamol by 50%, increases the hepatotoxicity. Ethanol reduces the concentration of ascorbic acid in the body, and also promotes the development of acute pancreatitis. The use of barbiturates reduces the effectiveness of paracetamol, increases the excretion of ascorbic acid in the urine. Strengthens the effect of hypnotic drugs.

    With simultaneous application with chloramphenicol, it is possible to increase the period of its half-elimination from the blood plasma and increase the toxic effect.

    Drugs that lead to a delay in emptying the stomach, for example propantheline, can lead to a slow absorption of paracetamol and, thus, delay the onset of its action.

    Drugs that lead to accelerated emptying of the stomach, for example metoclopramide, can lead to a faster absorption of paracetamol and, thus, accelerate the onset of its action.

    Tropisetron and granisetron antagonists, 5-hydroxytryptamine type 3 can completely inhibit the analgesic effect of paracetamol through pharmacodynamic interaction.

    Paracetamol should not be taken together with zidovudine without the recommendation of a doctor because of the increasing tendency to decrease the number of white blood cells (neutropenia).

    Continuous combination therapy with more than one analgesic should be avoided; because of the possible summation of side effects.

    Special instructions:Given the ability of the drug to cause drowsiness, it should be within 4 hours after taking the drug to release children from school, requiring increased concentration. Contains natural sugar.Each packet contains 1 XE. It was reported about very rare cases of serious skin reactions. In case of skin redness, rashes, blisters or scaling, stop using paracetamol and consult a doctor immediately. Paracetamol and ascorbic acid can distort the indicators of laboratory studies (quantitative determination of glucose and uric acid in the plasma, bilirubin, the activity of "liver" transaminases, LDH). With hyperthermia, lasting more than 3 days and pain syndrome for more than 5 days, a doctor's consultation is required.
    Effect on the ability to drive transp. cf. and fur:

    Given the ability of the drug to cause drowsiness, it should be within 4 hours after taking the drug to release children from school, requiring increased concentration.

    Form release / dosage:

    Powder for solution for oral administration 160 mg + 1 mg + 50 mg.

    Packaging:For 12 g in sachets of laminated foil. 5 or 8 bags together with instructions for medical use are placed in a cardboard box.
    Storage conditions:

    At a temperature of no higher than 25 ° C.

    Keep out of the reach of children.

    Shelf life:

    3 years.

    Do not use after expiry date.

    Terms of leave from pharmacies:Without recipe
    Registration number:LS-000415
    Date of registration:05.04.2010 / 01.06.2016
    Expiration Date:Unlimited
    The owner of the registration certificate:BAYER, AO BAYER, AO Russia
    Manufacturer: & nbsp
    Representation: & nbspBayer HellsCare AG Bayer HellsCare AG Germany
    Information update date: & nbsp07.09.2017
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