Desgrippin - instructions for use, dose, side effects, contraindications

Excipients: sodium hydrogen carbonate 828.8 mg, citric acid 952.7 mg, sorbitol 700.0 mg, povidone K-30 20.0 mg, sodium saccharinate 30.0 mg, sodium carbonate 93.0 mg, macrogol 70.0 mg, sodium lauryl sulfate 0.5 mg, flavor "Limon-Lime" 95.0 mg.

Description:Round, flat-cylindrical tablets, white or almost white with a barely noticeable marble; with chamfer, on one side with a risk; with a fruity smell.

Pharmacotherapeutic group:ARI and "colds" of symptoms remedy (analgesic non-narcotic means + H1-histamine receptor blocker + vitamin)

ATX: & nbsp

N.02.B.E.51 Paracetamol in combination with other drugs, excluding psycholeptics

Pharmacodynamics:

Paracetamol has analgesic and antipyretic effect; eliminates headache and other types of pain, reduces fever.

Ascorbic acid (vitamin C) participates in the regulation of oxidation-reduction processes, carbohydrate metabolism, increases the body's resistance.

Chlorphenamine - blocker H₁-gistaminovyh receptors, has anti-allergic effect, facilitates breathing through the nose, reduces the feeling of nasal congestion, sneezing, lacrimation, itching and redness of the eyes.

Indications:

Infectious and inflammatory diseases (acute respiratory infections, influenza), accompanied by fever, chills, headache, joint and muscle pain, nasal congestion and pain in the throat and sinuses of the nose.

Contraindications:

Hypersensitivity to paracetamol, ascorbic acid, chlorphenamine or any other component of the drug.

Erosive-ulcerative lesions of the gastrointestinal tract (in the phase of exacerbation).

Pronounced renal and / or hepatic insufficiency.

Alcoholism.

Closed-angle glaucoma.

Fructose intolerance (contains sorbitol).

Portal hypertension.

Hyperplasia of the prostate.

Children's age (up to 15 years).

Pregnancy and the period of breastfeeding.

Carefully:

Renal and / or hepatic insufficiency, deficiency of glucose-6-phosphate dehydrogenase, congenital hyperbilirubinemia (Gilbert syndrome, Dubin-Johnson and Rotor syndrome), hyperoxaluria, progressive malignant diseases, viral hepatitis, alcoholic hepatitis, elderly age, simultaneous or during the previous 2 weeks monoamine oxidase inhibitors (MAO), tricyclic antidepressants; simultaneous reception of drugs that can adversely affect the liver; diabetes; in patients with bronchial asthma, chronic bronchitis.

Pregnancy and lactation:

Use during pregnancy and during breastfeeding is not recommended.

Dosing and Administration:

Inside.

Adults and children over 15 years of age 1 tablet 2-3 times a day. The tablet should be completely dissolved in a glass (200 ml) of warm water (50-60 ° C) and the resulting solution immediately drink. It is better to take the drug between meals. The maximum daily dose is 3 tablets. The interval between doses should be at least 4 hours.

In patients with impaired liver or kidney function and in elderly patients the interval between doses should be at least 8 hours.

Duration of admission without consulting a doctor is no more than 5 days when prescribed as an anesthetic and 3 days as an antipyretic.

Side effects:

The drug is well tolerated at recommended doses.

Very rare:

from the side of the central nervous system: headache, fatigue;

from the digestive tract: nausea, pain in the epigastric region;

from the endocrine system: hypoglycemia (up to the development of coma);

from the hematopoiesis: anemia, hemolytic anemia (especially for patients with deficiency of glucose-6-phosphate dehydrogenase); extremely rare - thrombocytopenia;

serious reactions from the skin: acute generalized exanthematous pustulosis;

allergic reactions: skin rash, itching, urticaria, angioedema, anaphylactoid reactions (including anaphylactic shock), multiforme exudative erythema (including Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome);

Other: hypervitaminosis, metabolic disorders, sensation of heat, dry mouth, paresis of accommodation, urine retention, drowsiness, mydriasis, hepatotoxic effect, nephrotoxicity, bronchospasm.

All side effects of the drug should be reported to the doctor.

Overdose:

Symptoms of an overdose of the drug are due to the substances in its composition. The clinical picture of acute paracetamol overdose develops within 6-14 hours after its administration. Symptoms of chronic overdose appear after 2-4 days after increasing the dose of the drug.

Symptoms of acute paracetamol overdose: diarrhea, decreased appetite, nausea and vomiting, abdominal discomfort and / or abdominal pain, increased sweating, metabolic acidosis (including lactic acidosis); the overdose threshold may be reduced in elderly patients and children, in patients taking certain medicines (eg, inducers of microsomal liver enzymes), alcohol or suffering from malnutrition.

Symptoms of an overdose of chlorphenamine: dizziness, agitation, sleep disorders, depression, convulsions.

Treatment: symptomatic.

Interaction:

Increases the concentration in the blood of benzylpenicillin and tetracyclines.

Improves absorption in the intestines of iron preparations (converts trivalent iron into bivalent); can increase the excretion of iron with simultaneous use with deferoxamine.

Increases the risk of developing crystalluria in the treatment of salicylates and sulfonamides short-acting, slows the excretion of the kidney acids, increases the excretion of drugs that have an alkaline reaction (including alkaloids), reduces the concentration of oral contraceptives in the blood. Increases the total clearance of ethanol.

Ethanol enhances the sedative effect of antihistamine drugs.

Antidepressants, antiparkinsonian agents, antipsychotics (phenothiazine derivatives) - increase the risk of side effects (urinary retention, dry mouth, constipation).

Glucocorticosteroids - increase the risk of developing glaucoma.

With simultaneous use reduces the chronotropic effect of isoprenaline.

Can both increase and decrease the effect of anticoagulant drugs.

Reduces the therapeutic effect of antipsychotic drugs (neuroleptics) - derivatives of phenothiazine,tubular reabsorption of amphetamine and tricyclic antidepressants.

Inductors of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites, which allows the development of severe intoxication with small overdoses. Ethanol promotes the development of acute pancreatitis.

Inhibitors of microsomal oxidation (incl. cimetidine) reduce the risk of hepatotoxic effects. Simultaneous administration of the drug and diflunisala increases the concentration of paracetamol in the blood plasma by 50%, hepatotoxicity increases.

Simultaneous reception of barbiturates reduces the effectiveness of paracetamol, increases excretion of ascorbic acid in the urine.

Paracetamol reduces the effectiveness of uricosuric drugs.

Strengthens the effect of hypnotic drugs.

Special instructions:

When taking metoclopramide, domperidone, or colestyramine, it is also necessary to consult a doctor.

With prolonged use in doses much higher than recommended, the probability of impaired liver and kidney function increases,it is necessary to control the peripheral blood picture.

Paracetamol and ascorbic acid may distort the indicators of laboratory studies (quantitative determination of glucose and uric acid in the blood plasma, bilirubin, activity of "liver" transaminases, LDH).

To avoid toxic damage to the liver paracetamol should not be combined with the reception of alcoholic beverages, but also to people prone to chronic alcohol consumption. The risk of liver damage increases in patients with alcoholic hepatosis.

Assigning ascorbic acid to patients with rapidly proliferating and intensely metastatic tumors can aggravate the course of the process.

In patients with elevated iron levels in the body, ascorbic acid should be used in minimal doses.

Effect on the ability to drive transp. cf. and fur:

When using the drug, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require an increased concentration of attention and speed of psychomotor reactions.

Form release / dosage:

Tablets are effervescent, 500 mg + 10 mg + 200 mg.

Packaging:

For 10 tablets in a plastic pencil case or polymer tubes, complete with a lid, or a plastic pencil case or in polymer tubes, complete with lids with silica gel inserts.

1 pencil case or 1 tube together with the instruction for use is placed in a pack of cardboard.

1 a tablet into a contour non-jellied package made of a combined material based on paper, aluminum and polyethylene, or foil aluminum lacquered.

2 the tablets are joined in a 1 strip.

By 3, 4, 5, 6, 10 contour non-jawed packages (strips), together with instructions for use, are placed in a pack of cardboard.

Storage conditions:

In a dry, the dark place at a temperature of no higher than 30 ° C.

Keep out of the reach of children.

Shelf life:

3 of the year.

Do not use after expiry date.

Terms of leave from pharmacies:Without recipe

Registration number:LP-004055

Date of registration:29.12.2016

Expiration Date:29.12.2021

The owner of the registration certificate:NGO Farmvilar, OOO NGO Farmvilar, OOO Russia

Manufacturer: & nbsp

NGO Farmvilar, OOO Russia

Information update date: & nbsp27.01.2017

Illustrated instructions

Instructions

Desgrippin® (Dezgrippin)