Antigrippin - instructions for use, dose, side effects, contraindications

Excipients: sodium hydrogencarbonate 826.40 mg, citric acid 950.40 mg, sorbitol 700.00 mg, povidone 25.00 mg, sodium saccharinate 30.00 mg, sodium carbonate 93.00 mg, macrogol 70.00 mg, sodium lauryl sulfate 0, 20 mg, aromatizatorimovy (aromatic fruit additive "Lime") 95.00 mg.

Description:

The tablets are round, flat, with a bevelled edge and separation risk on one side, white or almost white, with a barely noticeable marble, with a fruity odor.

Pharmacotherapeutic group:ARI and "colds" of symptoms remedy (analgesic non-narcotic means + H1-histamine receptor blocker + vitamin)

ATX: & nbsp

N.02.B.E.51 Paracetamol in combination with other drugs, excluding psycholeptics

Pharmacodynamics:

Combined drug.

Paracetamol has analgesic and antipyretic effect; eliminates headache and other types of pain, reduces fever.

Ascorbic acid (vitamin C) participates in regulation oxidation-reduction processes, carbohydrate metabolism, increases the body's resistance.

Chlorphenamine - blocker H₁-histamine receptors, has an anti-allergic effect, facilitates breathing through the nose, reduces the feeling of nasal congestion, sneezing, lacrimation, itching and redness of the eyes.

Indications:

Infectious and inflammatory diseases (acute respiratory infections, influenza), accompanied by fever, chills, headache, joint and muscle pain, nasal congestion and pain in the throat and sinuses of the nose.

Contraindications:

- Hypersensitivity to paracetamol, ascorbic acid, chlorphenamine or any other component of the drug;

- Erosive-ulcerative lesions of the gastrointestinal tract (in the phase of exacerbation);

- Pronounced renal and / or hepatic insufficiency;

- Alcoholism;

- Closed-angle glaucoma;

- Phenylketonuria;

- Hyperplasia of the prostate;

- Children's age (up to 15 years);

- Pregnancy and lactation.

Carefully:

Renal and / or hepatic insufficiency, deficiency of glucose-6-phosphate dehydrogenase, congenital hyperbilirubinemia (Gilbert syndrome, Dubin-Johnson and Rotor syndrome), viral hepatitis, alcoholic hepatitis, elderly age.

Dosing and Administration:

Inside. Adults and children over 15 years of age take 1 tablet 2-3 times a day. The tablet should be completely dissolved in a glass (200 ml) of warm water (50-60 ° C) and the resulting solution immediately drunk. It is better to take the drug between meals. The maximum daily dose is 3 tablets. The interval between doses should be at least 4 hours.

In patients with impaired liver or kidney function and in elderly patients, the interval between doses should be at least 8 hours.

Duration of admission without consulting a doctor is no more than 5 days when prescribed as an anesthetic and 3 days as an antipyretic.

Side effects:

The drug is well tolerated at recommended doses.

In single cases there are:

from the central nervous system: headache, fatigue;

from the digestive tract: nausea, pain in the epigastric region;

from the endocrine system: hypoglycemia (up to the development of coma);

from the hematopoiesis: anemia, hemolytic anemia (especially for patients with deficiency of glucose-6-phosphate dehydrogenase); extremely rare - thrombocytopenia;

allergic reactions: skin rash, itching, urticaria, angioedema;

other: hypervitaminosis, metabolic disorders, sensation of heat, dry mouth, paresis of accommodation, urinary retention, drowsiness.

All side effects of the drug should be reported to the doctor.

Overdose:

Symptoms of an overdose of the drug are due to the substances in its composition. The clinical picture of acute paracetamol overdose develops within 6-14 hours after its administration. Symptoms of chronic overdose appear after 2-4 days after an overdose.

Symptoms of acute intoxication with paracetamol: diarrhea, decline appetite, nausea and vomiting, discomfort in the abdominal cavity and / or abdominal pain, increased sweating.

Symptoms of chlorphenamine intoxication: dizziness, agitation, sleep disorders, depression, convulsions.

Treatment: symptomatic.

Interaction:

Ethanol enhances the sedative effect of antihistamines.

Antidepressants, antiparkinsonian agents, antipsychotics (phenothiazine derivatives) - increase the risk of side effects (urinary retention, dry mouth, constipation). Glucocorticosteroids - increase the risk of developing glaucoma.

With simultaneous use reduces the chronotropic effect of isoprenaline.

Reduces the therapeutic effect of antipsychotic drugs (neuroleptics) - derivatives of phenothiazine, tubular reabsorption of amphetamine and tricyclic antidepressants.

Inductors of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites, which makes possible the development of heavy intoxication with small overdoses. Ethanol promotes the development of acute pancreatitis.

Inhibitors of microsomal oxidation (incl. cimetidine) reduce the risk of hepatotoxic effects. Simultaneous administration of the drug and diflunisala increases the concentration of paracetamol in the blood plasma by 50%, hepatotoxicity increases.Simultaneous reception of barbiturates reduces the effectiveness of paracetamol, increases the excretion of ascorbic acid in the urine.

Paracetamol reduces the effectiveness of uricosuric drugs.

Special instructions:

When taking metoclopramide, domperidone, or colestyramine, it is also necessary to consult a doctor.

With prolonged use in doses much higher than recommended, the probability of impaired liver and kidney function is increased, control of the peripheral blood picture is necessary.

Paracetamol and ascorbic acid may distort the indicators of laboratory studies (quantitative determination of glucose and uric acid in the blood plasma, bilirubin, activity of "liver" transaminases, LDH).

To avoid toxic damage to the liver paracetamol should not be combined with the reception of alcoholic beverages, but also to people prone to chronic alcohol consumption. The risk of liver damage increases in patients with alcoholic hepatosis. Assigning ascorbic acid to patients with rapidly proliferating and intensely metastatic tumors can aggravate the course of the process.In patients with elevated iron levels in the body, ascorbic acid should be used in minimal doses.

Form release / dosage:The tablets are effervescent.

Packaging:

10 tablets in a plastic case; on 1,2, 4 or 6 tablets in a strip of Al / Al.

By 1, 3, 5, 6, 10, 15, 20 strips in the cardboard pack together with instructions for use.

For 1 pencil case in a cardboard box or bundle-envelope with a device for with instructions for application.

Storage conditions:

At a temperature of 10-30 ° C.

Keep out of the reach of children!

Shelf life:

3 years.

Do not use after the expiration date.

Terms of leave from pharmacies:Without recipe

Registration number:П N015187 / 01

Date of registration:12.08.2009 / 27.03.2014

Expiration Date:Unlimited

The owner of the registration certificate:VALEANT, LLC VALEANT, LLC Russia

Manufacturer: & nbsp

NATUR PRODUKT PHARMA, Sp. z o.o. Poland

Representation: & nbspVALEANT LLC VALEANT LLC Russia

Information update date: & nbsp06.09.2017

Illustrated instructions

Instructions

Antigrippin (Antigrippin)